TS-One Contraindications

TS-ONE is contraindicated in the following patients.
Patients with a history of severe hypersensitivity to the ingredients of TS-ONE.
Patients with severe bone marrow depression: Bone marrow depression may be aggravated.
Patients with severe renal disorder: The urinary excretion of gimeracil, a catabolic enzyme inhibitor of fluorouracil (5-FU), is markedly decreased, thereby the blood concentration of 5-FU is increased. These suggest that adverse reactions such as bone marrow depression may be enhanced (see Pharmacology: Pharmacokinetics under Actions).
Patients with severe hepatic disorder: Hepatic disorder may be aggravated.
Patients receiving treatment with other fluoropyrimidine-group anticancer drugs including combination therapies with them (see Interactions).
Patients receiving treatment with flucytosine (see Interactions).
Pregnant women or women suspected of being pregnant (see Use in Pregnancy & Lactation).
Patients with known complete dihydropyrimidine dehydrogenase (DPD) deficiency (see Precautions).