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Syntometrine

Syntometrine

oxytocin + ergometrine

Manufacturer:

Alliance Pharma

Distributor:

DCH Auriga - Healthcare
/
Four Star
Concise Prescribing Info
Contents
Per mL Ergometrine maleate 500 mcg, oxytocin 5 IU
Indications/Uses
Active management of 3rd stage of labour (to promote separation of the placenta & to reduce blood loss). Prevention or treatment of postpartum haemorrhage following birth of the placenta.
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Dosage/Direction for Use
Active management of 3rd stage of labour 1 mL IM after delivery of the anterior shoulder or immediately after delivery of the child. Prevention & treatment of postpartum haemorrhage 1 mL IM following expulsion of the placenta or when bleeding occurs.
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Overdosage
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Contraindications
Hypersensitivity. Primary or secondary uterine inertia; severe HTN, pre-eclampsia, eclampsia; severe cardiac disorders, severe hepatic or renal impairment; occlusive vascular disease; sepsis. Pregnancy & labour (induction, 1st & 2nd stage of labour prior to delivery of the anterior shoulder).
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Special Precautions
Reports of anaphylaxis in women w/ known latex allergy. Should not be given until after delivery of the child, in breech presentations & other abnormal presentations; in multiple births, not until the last child has been delivered. Caution in patients w/ Raynaud's phenomenon; CAD; mild or moderate HTN, cardiac disorder, or hepatic or renal impairment. Potentially arrhythmogenic. Avoid concomitant use w/ strong CYP3A4 inhibitors. Caution when using w/ vasoconstrictors or other ergot alkaloids; prostaglandins & their analogues. Possibility of dizziness & hypotension. Avoid repeated use as it can suppress lactation.
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Adverse Reactions
Anaphylactic/anaphylactoid reactions associated w/ dyspnoea, hypotension, collapse or shock; headache, dizziness; MI, coronary arteriospasm, bradycardia, cardiac arrhythmias, chest pain; HTN; vomiting, nausea, abdominal pain; rash, angioedema.
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Drug Interactions
May enhance vasopressor effects of vasoconstrictors & sympathomimetics. Syntometrine can potentiate uterine action of prostaglandins & analogues & vice versa. Potential diminished uterotonic effect w/ inhalation anaesth. Oxytocin: Potential additive effect on QT interval w/ drugs which prolong the QT interval. Ergometrine: Possible raised levels of ergot derivatives w/ strong CYP3A4 inhibitors. Increased risk of severe & persistent spasm of major arteries w/ other ergot alkaloids (eg, methysergide) & other ergot derivatives. Additive vasoconstriction w/ triptans (eg, sumatriptan, zolmitriptan, rizatriptan, almotriptan, eletriptan). Possible enhanced vasoconstrictive action of ergot alkaloids w/ β-blockers. Reduced effect of glyceryl trinitrate & other antianginal drugs. Potential reduced clinical effect w/ CYP3A4 inducers (eg, nevirapine, rifampicin).
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Caution For Usage
For caution against possible variation of physical aspect of medicine... Click to view Syntometrine detailed prescribing information
Storage
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Description
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Action
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MIMS Class
Drugs Acting on the Uterus
ATC Classification
G02AC - Ergot alkaloids and oxytocin incl. analogues, in combination ; Used to induce abortion or augment labour and to minimize blood loss from the placental site.
Presentation/Packing
Form
Syntometrine soln for inj
Packing/Price
1 mL x 100 × 1's
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