Adult Schizophrenia Administer bd. Total daily dose for the 1st 4 days: 50 mg (day 1), 100 mg (day 2), 200 mg (day 3), 300 mg (day 4). Day 4 onwards: Titrate to the usual effective dose of 300-450 mg/day.
Moderate to severe manic episodes in bipolar disorder Administer bd. Total daily dose for the 1st 4 days: 100 mg (day 1), 200 mg (day 2), 300 mg (day 3), 400 mg (day 4). Dose adjustments up to 800 mg/day by day 6 should be in increments of no greater than 200 mg/day. Usual effective dose: 400-800 mg/day.
Major depressive episodes in bipolar disorder Administer once daily at bedtime. Total daily dose for the 1st 4 days: 50 mg (day 1), 100 mg (day 2), 200 mg (day 3), 300 mg (day 4). Recommended daily dose: 300 mg.
Preventing recurrence in bipolar disorder Continue w/ the previous dosing. May be adjusted w/in the range of 300-800 mg/day bd.