Remeron Dosage/Direction for Use

Adults: The effective daily dose is usually between 15 and 45 mg; the starting dose is 15 or 30 mg. Mirtazapine begins to exert its effect in general after 1-2 weeks of treatment. Treatment with an adequate dose should result in a positive response within 2-4 weeks. With an insufficient response, the dose can be increased up to the maximum dose. If there is no response within a further 2-4 weeks, then treatment should be stopped.
Elderly: The recommended dose is the same as that for adults. In elderly patients an increase in dosing should be done under close supervision to elicit a satisfactory and safe response.
Children and adolescents under the age of 18 years: Remeron should not be used in children and adolescents under the age of 18 years (see Precautions) as efficacy was not demonstrated in two short-term clinical trials (see Pharmacology: Pharmacodynamics under Actions) and because of safety concerns (see Pharmacology: Pharmacodynamics under Actions, Precautions and Adverse Reactions).
Renal impairment: The clearance of mirtazapine may be decreased in patients with moderate to severe renal impairment (creatinine clearance <40 ml/min). This should be taken into account when prescribing Remeron to this category of patients (see Precautions).
Hepatic impairment: The clearance of mirtazapine may be decreased in patients with hepatic impairment. This should be taken into account when prescribing Remeron to this category of patients, particularly with severe hepatic impairment, as patients with severe hepatic impairment have not been investigated (see Precautions).
Mirtazapine has an elimination half-life of 20-40 hours and therefore Remeron is suitable for once-a-day administration. It should be taken preferably as a single night-time dose before going to bed. Remeron may also be given in two divided doses (once in the morning and once at night-time, the higher dose should be taken at night).
The tablets should be taken orally. The tablet will rapidly disintegrate and can be swallowed without water.
Patients with depression should be treated for a sufficient period of at least 6 months to ensure that they are free from symptoms.
It is recommended to discontinue treatment with mirtazapine gradually to avoid withdrawal symptoms (see Precautions).