Prograf Caution For Usage

Instructions for use/handling: Cap: To be used as directed. Patients should take the capsules immediately once they are taken out of the blister. In addition, patients should be cautioned not to swallow the desiccant sachet contained within the aluminium wrapper.
Inj: Prograf Concentrate for Solution for Infusion must not be injected undiluted.
Prograf Concentrate for Solution for Infusion should be diluted in 5% dextrose solution or physiological saline solution in polyethylene, polypropylene or glass bottles, but not in PVC containers (see Incompatibilities as follows). Only transparent and colourless solutions should be used.
The concentration of a solution for infusion should be within the range 0.004 - 0.100 mg/ml. The total volume of infusion during a 24-hour period should be in the range 20 - 500 ml.
The diluted solution should not be given as a bolus.
Any unused concentrate in an opened ampoule or unused reconstituted solution should be disposed of immediately to avoid contamination.
Incompatibilities: Cap: Tacrolimus is not compatible with PVC. Tubing, syringes and other equipment used to prepare or administer a suspension of Prograf capsule contents should not contain PVC.
Inj: When diluting, this medicinal product must not be mixed with other medicinal products except those mentioned previously.
Tacrolimus is absorbed by PVC plastics. Tubing, syringes and any other equipment used to prepare and administer Prograf Concentrate for Solution for Infusion 5 mg/ml should not contain PVC.
Tacrolimus is unstable under alkaline conditions. Combination of the reconstituted Prograf Concentrate for Solution for Infusion 5 mg/ml with other pharmaceutical products that produce a marked alkaline solution (e.g. aciclovir and ganciclovir) should be avoided.