Adult Schizophrenia & related psychotic disorders Initially 1-2 mg/day once daily or bd; adjust dose gradually over several days based on clinical response to a target dose of 4-6 mg/day. Further dose adjustments, if indicated, should be at 1 mg increments/decrements at intervals of not less than 1 wk.
Severe dementia of the Alzheimer type Initially 0.25 mg bd; adjust dose by increments of 0.25 mg/day approx every 2-4 days.
Bipolar mania 2-3 mg once daily; adjust dose at intervals of not less than 24 hr & in increments/decrements of 1 mg/day.
Elderly Schizophrenia Initially 0.25 mg bd; adjust slowly to a max daily dose of 3 mg.
Patient prone to hypotension Initially 0.25-0.5 mg bd.
Patient w/ hepatic impairment Schizophrenia & related psychotic disorders Initially 0.25-0.5 mg bd; adjust dose in 0.5 mg bd increments to 1-2 mg bd. Increases to >1.5 mg bd should generally occur at intervals of at least 1 wk.
Patients w/ renal impairment Initially 0.5 mg bd; increase dose in increments of no more than 0.5 mg bd. Increases to >1.5 mg bd should generally occur at intervals of at least 1 wk.