Potentiated CNS effects w/ anesthetics. Potentiated pharmacological effects w/ TCAs. Aggravated hyperkinetic symptoms w/ lithium. Increased CNS depressant effects w/ MAOIs. Additive effect in BP w/ antihypertensives. Risk of mental confusion, hallucinations, headache, nausea, agitation & worsening of symptoms of Parkinsonism w/ levodopa/carbidopa. Adjust dose of antidiabetic agents due to increased blood glucose conc w/ baclofen. Potential synergistic effect w/ Mg sulfate or other neuromuscular blocking agents. Reduced excretion w/ drugs or medicinal products that can significantly impact renal function (eg, memantine, NSAIDs). Increased sedation w/ other drugs causing CNS depression, including other muscle relaxants (eg, tizanidine), synthetic opiates, hypnotics, anxiolytics, alcohol.