Plendil

Plendil

felodipine

Manufacturer:

AstraZeneca

Distributor:

DCH Auriga - Healthcare
Concise Prescribing Info
Contents
Felodipine
Indications/Uses
Dosage/Direction for Use
Take in the morning. HTN Initially 5 mg once daily. Dose may be increased or another antihypertensive agent added. Maintenance: 5-10 mg once daily. Stable angina pectoris Initially 5 mg once daily, may be increased to 10 mg once daily if needed. Elderly Initial dose of 2.5 mg daily should be considered.
Administration
May be taken with or without food: Take w/o food or following a light meal not rich in fats or carbohydrates. Swallow whole w/ water, do not divide/chew/crush.
Contraindications
Hypersensitivity. Uncompensated heart failure, acute MI, unstable angina pectoris. Dynamic cardiac outflow obstruction. Haemodynamically significant cardiac valvular obstruction. Cardiogenic shock. Pregnancy.
Special Precautions
Risk of hypotension; may lead to myocardial ischemia in susceptible patients. Reports of mild gingival enlargement in patients w/ pronounced gingivitis/periodontitis; enlargement can be avoided or reversed by careful dental hygiene. Contains lactose; not to be given in patients w/ hereditary galactose intolerance or glucose-galactose malabsorption. May cause dizziness & fatigue; consider these effects when driving or operating machines. Patients w/ hepatic impairment or severe renal impairment. Lactation. Do not use in ped patients.
Adverse Reactions
Peripheral oedema. Headache; flushing; palpitations, dizziness & fatigue.
Drug Interactions
Decreased plasma levels w/ CYP3A4 inducers (eg, carbamazepine, phenytoin, phenobarb, rifampicin, St. John's wort). Increased plasma levels w/ CYP3A4 inhibitors (eg, itraconazole, ketoconazole, erythromycin, HIV PIs, grapefruit juice, cyclosporin, cimetidine). May increase tacrolimus conc.
MIMS Class
Calcium Antagonists / Anti-Anginal Drugs
ATC Classification
C08CA02 - felodipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.
Presentation/Packing
Form
Plendil XR tab 10 mg
Packing/Price
30's
Form
Plendil XR tab 2.5 mg
Packing/Price
300's;30's
Form
Plendil XR tab 5 mg
Packing/Price
300's;30's
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