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Metabolism/transport effects substrate of CYP1A2 (major), 2D6 (minor). Inhibits CYP1A2 (weak), 2C19 (weak), 2D6 (weak), 3A4 (weak).
Benzodiazepines, metoclopramide: Avoid concomitant use with olanzapine.
Alcohol (ethyl), anticholinergics, benzodiazepines, CNS depressants, methotrimeprazine, methylphenidate: Increased levels/toxicity/effects with olanzapine.
Acetylcholinesterases inhibitors (central), CYP1A2 inhibitors (moderate), CYP1A2 inhibitors (strong), droperidol, fluvoxamine, lamotrigine, lithium formulations, methotrimeprazine, methylphenidate, metoclopramide, pramlintide, tetrabenazine: Increased levels of olanzapine.
Amphetamines, anti-Parkinson's agents (dopamine agonist), quinagolide: Decreased levels/effects.
CYP1A2 inducers (strong), lithium formulations, peginterferon alfa-2b: decreased levels/effects of olanzapine.
Ethanol/Nutrition/Herb Interactions: Ethanol: Avoid ethanol (increased CNS depression).
Herb/Nutraceutical: Avoid dong quai, St. John's wort (may cause photosensitization); kava kava, gotu kola, valerian, St. John's wort (increased CNS depression).
