Treatment of all forms of episodic cardiac pain (arrestation of angina pectoris attacks). Prophylaxis of angina pectoris. Acute cardiac infarction. Acute myocardial insufficiency, w/ acutely impaired left ventricular function. Catheter-induced coronary spasms during coronary angiography.
Hypersensitivity. Acute circulatory failure; severe hypotension; cardiogenic shock, unless a sufficiently high left ventricular end-diastolic pressure is assured by intra-aortal counterpulsation or positive inotropic drugs; myocardial diseases concerning reduced cardiac vol; constructive pericarditis; pericardial tamponade; primary pulmonary HTN. Concomitant use w/ certain drugs for erectile dysfunction or pulmonary arterial HTN.
Careful medical supervision in patients w/ acute cardiac infarction w/ low filling pressures; aortic &/or mitral stenosis; orthostatic disturbances of circulatory regulation; diseases associated w/ increased intracranial pressure. Tolerance development & occurrence of cross tolerance to other nitro compounds. Attenuation of the haemodynamic effects w/in 24 hr. May impair ability to drive or operate machinery. Pregnancy & lactation.
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