Increased incidence of serotonin-associated effects w/ MAOIs or other serotonergic active substances (L-tryptophan, triptans, tramadol, linezolid, methylene blue, SSRIs, venlafaxine, lithium, St. John's Wort). May increase the sedating properties of benzodiazepines & other sedatives. May increase CNS depressant effect of alcohol. Increased INR w/ warfarin. Increased risk of QT prolongation &/or ventricular arrhythmias w/ concomitant use of medicines which prolong the QTc interval (eg, some antipsychotics & antibiotics). Decreased plasma conc w/ carbamazepine & phenytoin (CYP3A4 inducers). Increased peak plasma levels & AUC w/ potent CYP3A4 inhibitors (ketoconazole, HIV PIs, azole antifungals, erythromycin, cimetidine or nefazodone).