Patients w/ history of hypersensitivity to carbapenems, penicillins or other β-lactam antibiotics. Discontinue treatment if severe allergic reaction occurs. Reports of severe cutaneous adverse reactions eg, SJS, TEN, DRESS, erythema multiforme & acute generalised exanthematous pustulosis; antibiotic-associated colitis & pseudomembranous colitis; seizures. Risk of hepatic toxicity. Closely monitor hepatic function during treatment. May develop a +ve direct or indirect Coombs test. Not recommended w/ valproic acid/Na valproate/valpromide. Patients w/ renal impairment. Patients on a controlled Na diet. Preferable to avoid use of meropenem during pregnancy. Should not be used in breast-feeding women unless potential benefit for the mother justifies potential risk to the baby.
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