In combination w/ prednisone or prednisolone for the treatment of adult patients w/ metastatic castration resistant prostate cancer previously treated w/ a docetaxel-containing regimen.
View Jevtana overdosage for action to be taken in the event of an overdose.
Contraindications
Hypersensitivity to cabazitaxel, to other taxanes or polysorbate 80. Neutrophil count <1,500/mm3; severe hepatic impairment (total bilirubin ≥3 x ULN); concomitant vaccination w/ yellow fever vaccine.
Hypersensitivity reactions during 1st & 2nd infusions. Bone marrow suppression; risk of neutropenia. Discontinue or delay treatment in case of serious GI toxicity. Appropriate measures should be taken to rehydrate patients & to monitor & correct serum electrolyte levels, particularly K. Peripheral neuropathy (sensory & motor). Hb & haematocrit should be checked before treatment & if patients exhibit signs or symptoms of anaemia or blood loss. Risk of renal failure or cardiac arrhythmias. Interstitial pneumonia/pneumonitis & interstitial lung disease. Co-administration w/ strong CYP3A inhibitors or inducers. Hepatic impairment. Patients presenting end stage renal disease. Contains 573.3 mg ethanol 96%. May influence ability to drive & use machinery. Pregnancy & lactation.
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