Adult, adolescent & childn ≥4 yr (≥30 kg) Initially 400 mg daily dose, may be increased by 400 mg/day as frequently as every 2 days. Max: ≥70.1 kg 3,200 mg/day; 50.1-70 kg 2,400 mg/day; 30-50 kg 1,800 mg/day. Childn ≥4 yr, <30 kg not receiving valproate Initially 200 mg daily, may be increased by 200 mg/day increments as frequently as every 2 days. Max: 1,000 mg/day; <30 kg also receiving valproate medication Initially 200 mg daily dose. After a min of 2 days, dose may be increased by 200 mg/day. Max: 600 mg/day.
View Inovelon overdosage for action to be taken in the event of an overdose.
Administration
Should be taken with food: Take in the morning & evening w/ water. For patients w/ swallowing difficulties, crush tab & administer in ½ glass of water.
Contraindications
Hypersensitivity to rufinamide or triazole derivatives.
Status epilepticus. W/draw or gradually to reduce the possibility of seizures on w/drawal. Associated w/ dizziness, somnolence, ataxia & gait disturbances. Serious antiepileptic drug hypersensitivity syndrome including drug reaction w/ eosinophilia & systemic symptoms (DRESS) & Stevens-Johnson syndrome. Lymphadenopathy, liver function test abnormalities & haematuria. Discontinue use & start alternative treatment if reaction is suspected. Decrease in QTc interval proportional to conc. Women of childbearing potential. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Monitor for signs of suicidal ideation & behaviour. Hepatic impairment. Lactation. Elderly >65 yr. Childn ≤4 yr.
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