Postpone vaccination in subjects suffering from acute severe febrile illness. If any of the following occurs, the decision to give subsequent doses of pertussis-containing vaccine should be carefully considered: Rectal temp ≥40°C w/in 48 hr, not due to another identifiable cause; collapse or shock-like state w/in 48 hr of vaccination; persistent, inconsolable crying lasting ≥3 hr, w/in 48 hr of vaccination; convulsions w/ or w/o fever, w/in 3 days of vaccination. Childn w/ progressive neurological disorders, including infantile spasms, uncontrolled epilepsy or progressive encephalopathy; subjects w/ thrombocytopenia or bleeding disorder; hypersensitivity to neomycin & polymyxin; immunosuppressed patients. Do not administer IV. Not recommended in adults, adolescents or childn >5 yr. +ve urine test for Hib capsular polysaccharide antigen w/in 1-2 wk of vaccination. Potential risk of apnoea & the need for resp monitoring for 48-72 hr should be considered for very premature infants (born ≤28 wk of gestation) & those w/ history of resp immaturity.
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