Patient not switching from other fentanyl containing products Initially 100 mcg, titrating upwards as necessary through the range of available strengths. Patient switching from other fentanyl containing products Starting dose >100 mcg may be considered.
View Fentora overdosage for action to be taken in the event of an overdose.
Administration
Should be taken on an empty stomach: Place & retain the tab w/in the buccal cavity until the tab disintegrate approx 14-25 min. After 30 min, if remnants from the tab remain, drink a glass of water. Alternatively, take sublingually. Do not suck/chew/swallow.
Contraindications
Hypersensitivity; patients w/ maintenance opioid therapy may increase risk of resp depression; severe resp depression or severe obstructive lung conditions; treatment of acute pain other than breakthrough pain.
Resp depression. Patients w/ non-severe COPD or other medical conditions predisposing to resp depression may further decrease resp drive to the point of resp failure. Patients particularly susceptible to the intracranial effects of CO2 retention (eg, increased ICP or impaired consciousness). May produce bradycardia. Hepatic or renal impairment. Concomitant use of serotonergic drugs eg, SSRIs & serotonin norepinephrine reuptake inhibitors, & w/ drugs which impair metabolism of serotonin including MAOIs. Tolerance & physical &/or psychological dependence may develop. Patients on a controlled Na diet. Anaphylaxis & hypersensitivity. Opioid analgesics impair the mental &/or physical ability required for the performance of potentially dangerous tasks. Pregnancy & lactation. Childn. Elderly >65 yr.
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