View Erleada overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food: Swallow whole, do not crush. For patients w/ swallowing difficulties, mix whole tab in 120 mL applesauce & wait for 15 min then stir. Wait for another 15 mins then stir mixt until tab is dispersed & consume immediately.
Special Precautions
Monitor for signs & symptoms of ischemic heart disease & cerebrovascular disorders. Consider discontinuation for grade 3 & 4 cerebrovascular & ischemic CV events. Evaluate patients for fracture &/or fall risk. Permanently discontinue in patients who develop seizure during treatment. Advise males w/ female partners of reproductive potential to use effective contraception during treatment & for 3 mth after the last dose. Can cause fetal harm & loss of pregnancy.
Possible increase in steady-state exposure w/ strong CYP2C8 or CYP3A4 inhibitors. Lowered exposure of CYP3A4, CYP2C9, or CYP2C19 substrates; UGT substrates; P-gp, BCRP, or OATP1B1 substrates.
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