Nucleoside-treatment naïve adult & adolescent ≥16 yr 0.5 mg once daily.
Adult & adolescent ≥16 yr w/ history of hepatitis B viremia while receiving lamivudine or known lamivudine resistance mutations 1 mg once daily.
Patient w/ renal impairment CrCl ≥50 mL/min Usual dose: 0.5 mg once daily. Lamivudine-refractory: 1 mg once daily,
CrCl 30 to <50 mL/min Usual dose: 0.5 mg every 48 hr. Lamivudine-refractory: 0.5 mg once daily or 1 mg every 48 hr,
CrCl 10 to <30 mL/min Usual dose: 0.5 mg every 72 hr. Lamivudine-refractory: 1 mg every 72 hr,
CrCl <10 mL/min or patient on hemodialysis or continuous ambulatory peritoneal dialysis Usual dose: 0.5 mg every 7 days. Lamivudine-refractory dose: 1 mg every 7 days.
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