Search

Endoxan

Endoxan

cyclophosphamide

Manufacturer:

Baxter Healthcare

Distributor:

Baxter Healthcare
/
Firma Chun Cheong
Concise Prescribing Info
Contents
Cyclophosphamide monohydrate
Indications/Uses
Leukemias, malignant lymphomas, metastasizing & non-metastasizing malignant solid tumors, progressive autoimmune diseases, immunosuppressive treatment in organ transplantations.
Click to view Endoxan detailed prescribing information
Dosage/Direction for Use
Tab 1-4 tab daily in the morning. Inj Continuous treatment 3-6 mg/kg daily. Intermittent treatment 10-15 mg/kg at intervals of 2-5 days. High-dose intermittent treatment 20-40 mg/kg at intervals of 21-28 days.
Click to view Endoxan detailed prescribing information
Overdosage
View Endoxan overdosage for action to be taken in the event of an overdose.
Contraindications
Hypersensitivity. Severely impaired bone marrow function (especially patients pre-treated w/ cytotoxic agents &/or radiotherapy). Inflammation of the bladder. Urinary outflow obstructions, active infections. Pregnancy & lactation.
Click to view Endoxan detailed prescribing information
Special Precautions
Obstruction of the efferent urinary tract, cystitis, infections & electrolyte imbalance. Elderly & debilitated patients, previous radiotherapy, DM, chronic hepatic or renal impairment. Pre-existing heart disease. Weakened immune system. Monitor blood count. Ensure adequate fluid intake. May affect ability to drive or operate machinery.
Click to view Endoxan detailed prescribing information
Adverse Reactions
Blood & bone marrow disorders, GI disturbances, kidney & efferent urinary tract changes. Cystitis. Azoospermia or persistent oligospermia, ovulation disorders, amenorrhea. Disturbance of hepatic function. Veno-occlusive disease. Chronic interstitial pulmonary fibrosis, cardiomyopathy. Secondary tumors. Alopecia, pigment changes in palms, finger nails & soles.
Click to view Endoxan detailed prescribing information
Drug Interactions
Sulfonylureas, allopurinol, hydrochlorothiazide, phenobarb, phenytoin, benzodiazepines, chloral hydrate, vaccines, muscle relaxants, chloramphenicol, anthracyclines, pentostatin, indomethacin, alcohol, grapefruit.
Click to view Endoxan detailed prescribing information
Caution For Usage
For caution against possible variation of physical aspect of medicine... Click to view Endoxan detailed prescribing information
Storage
View Endoxan storage conditions for details to ensure optimal shelf-life.
Description
View Endoxan description for details of the chemical structure and excipients (inactive components).
Action
View Endoxan mechanism of action for pharmacodynamics and pharmacokinetics details.
MIMS Class
Cytotoxic Chemotherapy
ATC Classification
L01AA01 - cyclophosphamide ; Belongs to the class of alkylating agents, nitrogen mustard analogues. Used in the treatment of cancer.
Presentation/Packing
Form
Endoxan powd for inj 1 g
Packing/Price
1's
Form
Endoxan powd for inj 200 mg
Packing/Price
1's
Form
Endoxan sugar-coated tab 50 mg
Packing/Price
50's
Exclusive offer for doctors
Register for a MIMS account and receive free medical publications worth $768 a year.
Already a member? Sign in
Exclusive offer for doctors
Register for a MIMS account and receive free medical publications worth $768 a year.
Already a member? Sign in