Adjunctive therapy to diet to reduce elevated total-cholesterol, LDL-cholesterol, apolipoprotein B, nonHDL-cholesterol & triglycerides levels & to increase HDL-cholesterol in adult patients w/ primary hyperlipidemia & mixed dyslipidemia. Adjunct to diet to reduce total-cholesterol, LDL-cholesterol & apolipoprotein B levels in adolescent boys & girls, who are at least 1 yr post-menarche, 10-17 yr of age w/ heterozygous familial hypercholesterolemia (HeFH) (LDL-cholesterol >190 or >160 mg/dL & positive family history of premature CV disease (CVD) or ≥2 other CVD risk factors). Adjunctive therapy to diet in adult patients w/ hypertriglyceridemia. Adjunct to diet in patients w/ primary dysbetalipoproteinemia (Type III hyperlipoproteinemia). Adjunctive therapy to other lipid-lowering treatments (eg, LDL apheresis) or as monotherapy if such treatments are unavailable to reduce LDL-cholesterol, total-cholesterol & apolipoprotein B in adult patients w/ homozygous familial hypercholesterolemia. Adjunct to diet in slowing atherosclerosis progression in adult patients as part of treatment strategy to lower total-cholesterol & LDL-cholesterol. Primary prevention of CVD to reduce risk of stroke, MI & arterial revascularization procedures in patients w/o clinically evident CHD but w/ increased risk of CVD based on age ≥50 yr in men & ≥60 yr in women, hsCRP ≥2 mg/L & the presence of at least 1 additional CVD risk factor eg, HTN, low HDL-cholesterol, smoking, family history of premature CHD.