Adult Lower resp tract infection; acute exacerbation of chronic sinusitis; chronic suppurative otitis media 500-750 mg bd PO or 400 mg bd-tds IV for 7-14 days.
Malignant external otitis 750 mg bd PO or 400 mg tds IV for 28 days up to 3 mth.
Bacterial prostatitis 500-750 mg bd PO for 2-4 wk (acute) to 4-6 wk (chronic); or 400 bd-tds IV for 2-4 wk (acute).
Epididymo-orchitis & pelvic inflammatory diseases due to susceptible Neisseria gonorrhoeae 500-750 mg bd PO or 400 mg bd-tds IV for at least 14 days.
Diarrhoea caused by bacterial pathogens including Shigella spp. other than Shigella dysenteriae type 1 & empirical treatment of severe travellers' diarrhoea 500 mg bd PO or 400 mg bd IV for 1 day.
Diarrhoea caused by Shigella dysenteriae type 1 500 mg bd PO or 400 mg bd IV for 5 days.
Diarrhoea caused by Vibrio cholerae 500 mg bd PO or 400 mg bd IV for 3 days.
Typhoid fever 500 mg bd PO or 400 mg bd IV for 7 days.
Intra-abdominal infections due to gm -ve bacteria 500-750 mg bd PO or 400 mg bd-tds IV for 5-14 days.
Infections of the skin & soft tissue caused by gm -ve bacteria 500-750 mg bd PO or 400 mg bd-tds IV for 7-14 days.
Bone & joint infections 500-750 mg bd PO or 400 mg bd-tds IV for max 3 mth.
Neutropenic patients w/ fever that is suspected to be due to a bacterial infection 500-750 mg bd PO or 400 mg bd-tds IV continued over the entire period of neutropenia.
Inhalation anthrax post-exposure prophylaxis & curative treatment 500 mg bd PO or 400 mg bd IV for 60 days from the confirmation of
Bacillus anthracis exposure.
Childn Cystic fibrosis 20 mg/kg bd PO w/ a max of 750 mg per dose or 10 mg/kg tds IV w/ a max of 400 mg per dose, for 10-14 days.
Complicated UTI & acute pyelonephritis 10-20 mg/kg bd PO w/ a max of 750 mg per dose or 6 mg/kg tds IV w/ a max of 400 mg per dose, for 10-21 days.
Inhalation anthrax post-exposure prophylaxis & curative treatment 10-15 mg/kg bd PO w/ a max of 500 mg per dose or 10-15 mg/kg bd IV w/ a max of 400 mg per dose, for 60 days from the confirmation of
Bacillus anthracis exposure.
Other severe infections 20 mg/kg bd PO w/ a max of 750 mg per dose or 10 mg/kg tds IV w/ a max of 400 mg per dose.
Tab Acute uncomplicated cystitis 250-500 mg bd PO for 3 days. 500 mg single dose PO may be used in pre-menopausal women.
Complicated cystitis, acute pyelonephritis 500 mg bd PO for 7 days.
Complicated pyelonephritis 500-750 mg bd PO for at least 10 days, can be continued for >21 days in some specific circumstances (eg, abscesses).
Gonococcal urethritis & cervicitis due to susceptible Neisseria gonorrhoeae 500 mg single dose PO for 1 day.
Prophylaxis of invasive infections due to Neisseria meningitidis 500 mg single dose PO for 1 day.
IV Adult Acute & complicated pyelonephritis 400 mg bd-tds IV for 7-21 days, can be continued for >21 days in some specific circumstances (eg, abscesses).