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Use with other vaccines or immunoglobulins: Boostrix may be administered concomitantly with human papilloma virus vaccine with no clinically relevant interference with antibody response to any of the components of either vaccine.
Boostrix can be given concomitantly with meningococcal serogroups A, C, W-135 and Y (MenACWY) conjugate vaccines. Clinical studies in subjects aged 9 to 25 years demonstrated that the immune responses to the tetanus, diphtheria and meningococcal antigens were unaffected. Lower geometric mean concentrations (GMCs) were observed for the pertussis antigens; however, these data do not suggest clinically relevant interference.
Boostrix can be given concomitantly with unadjuvanted inactivated seasonal influenza vaccines. When Boostrix was co-administered with a trivalent inactivated influenza vaccine in subjects aged between 19 and 64 years, clinical data demonstrated that the immune responses to the tetanus, diphtheria, pertussis toxoid (PT) and influenza antigens were unaffected. Lower GMCs were observed for the pertussis filamentous haemagglutinin (FHA) and pertactin (PRN) antigens; however, these data do not suggest clinically relevant interference. No differences were observed in a predefined exploratory cohort when the vaccines were given concomitantly or separately to subjects aged 65 years and older.
Boostrix can be given concomitantly with non-live herpes zoster vaccine. Clinical data in subjects aged 50 years and older demonstrated that the immune responses to the tetanus, diphtheria, PT, FHA and herpes zoster antigens were unaffected. Lower GMCs were observed for the PRN antigen; however, these data do not suggest clinically relevant interference.
Concomitant administration of Boostrix with other vaccines or with immunoglobulins has not been studied. It is unlikely that co-administration with other inactivated vaccines or with immunoglobulins will result in clinically relevant interference with the immune responses.
According to generally accepted vaccine practices and recommendations, if concomitant administration of Boostrix with other vaccines or immunoglobulins is considered necessary, the products should be given at separate sites.
Use with immunosuppressive treatment: As with other vaccines, patients receiving immunosuppressive therapy may not achieve an adequate response.
