Betaferon Caution For Usage

Special precautions for disposal and other handling: Reconstitution: To reconstitute lyophilised interferon beta-1b for injection, connect the vial adaptor with the attached needle on the vial. Connect the pre-filled syringe with solvent to the vial adapter and inject the 1.2 ml of the solvent (sodium chloride solution, 5.4 mg/ml (0.54% w/v)) into the Betaferon vial. Dissolve the powder completely without shaking.
After reconstitution, draw 1.0 ml from the vial into the syringe for the administration of 250 microgram Betaferon. For the dose titration at the start of treatment, draw the respective volume as given in Dosage & Administration.
Remove the vial with the vial adapter from the pre-filled syringe before injection.
Betaferon may also be administered with a suitable autoinjector.
Inspection prior to use: Inspect the reconstituted product visually before use. The reconstituted product is colourless to light yellow and slightly opalescent to opalescent.
Discard the product before use if it contains particulate matter or is discoloured.
Disposal: Any unused medicinal product or waste material should be disposed of in accordance with local requirements.
Incompatibilities: This medicinal product must not be mixed with other medicinal products except for the supplied solvent mentioned previously.