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Symptoms: No cases of overdose have been reported in clinical trials with avapritinib. The maximum dose of AYVAKIT studied clinically is 600 mg orally once daily. Adverse reactions observed at this dose were consistent with the safety profile at 300 mg or 400 mg once daily (see Adverse Reactions).
Management: There is no known antidote for AYVAKIT overdose. In the event of suspected overdose, AYVAKIT should be interrupted and supportive care instituted. Based on the large volume of distribution of avapritinib and extensive protein binding, dialysis is unlikely to result in significant removal of avapritinib.
