Additive effect on QT prolongation w/ anti-arrhythmics class IA (eg, quinidine, hydroquinidine, disopyramide); anti-arrhythmics class III (eg, amiodarone, sotalol, dofetilide, ibutilide); antipsychotics (eg, phenothiazines, pimozide, sertindole, haloperidol, sultopride); TCAs; certain antimicrobial agents (sparfloxacin, erythromycin IV, pentamidine, antimalarials particularly halofantrine); certain antihistamine (terfenadine, astemizole, mizolastine); cisapride, vincamine IV, bepridil, diphemanil. Enhanced anticoagulant effects of warfarin or its derivatives. Disturbances of blood glucose w/ antidiabetics. Increased risk of CNS stimulation & convulsions w/ NSAIDs.
Oral: Interference in absorption w/ antacids containing Al or Mg; sucralfate; metal cations eg, Fe; multivit containing Fe or Zn; formulations containing divalent & trivalent cations.