Increased blood sugar lowering effect w/ other antidiabetics (eg, insulin, metformin); NSAIDs (eg, phenylbutazone, azopropazone, oxyphenbutazone, aspirin-like medicines); drugs for UTI (eg, long acting sulfonamides); antibacterial & antifungal agents (eg, tetracyclines, chloramphenicol, fluconazole, miconazole, quinolones, clarithromycin); anticoagulants (coumarin derivatives eg, warfarin); anabolics; male sex hormone replacement therapy; antidepressants (eg, fluoxetine, MAOIs); antihypercholesterolemia (eg, fibrates); antihypertensives (eg, ACE inhibitors); antiarrhythmics (eg, disopyramide); antigout agents (eg, allopurinol, probenecid, sulfinpyrazone); antineoplastics (eg, cyclophosphamide, ifosfamide, trofosfamide); wt-reducing agents (eg, fenfluramine); agents used to increase circulation (eg, IV pentoxifylline); antihistamine (eg, tritoqualine); sympatholytics. Decreased blood sugar lowering effect w/ female sex hormones (eg, oestrogen, progestogens); antihypertensives (eg, thiazide diuretics); TSH (eg, levothyroxine); steroids (eg, glucocorticoids); antipsychotics (eg, chlorpromazine & other phenothiazine derivatives); adrenaline & sympathomimetics; antihypercholesterolemia (eg, nicotinic acid); laxatives; antiepileptics (eg, phenytoin); sedative-hypnotics (eg, barbiturates); anti-glaucoma (eg, acetazolamide); diazoxide; anti-TB (eg, rifampicin); glucagon. Altered blood sugar lowering effect w/ antiulcerants (eg, H
2 antagonists); β-blockers, clonidine, guanethidine, reserpine; alcohol. Altered effects of anticoagulants (coumarin derivatives eg, warfarin). Altered absorption w/ colesevelam.