Tab Multiple myeloma 0.15 mg/kg body wt/day in divided doses for 4 days repeated at intervals of 6 wk.
Advanced ovarian adenocarcinoma 0.2 mg/kg body wt/day for 5 days. Repeated 4-8 wkly or as soon as peripheral blood count has recovered.
Breast carcinoma 0.15 mg/kg body wt daily or 6 mg/m
2 BSA/day for 5 days & repeated 6 wkly.
Polycythaemia rubra vera Remission induction: 6-10 mg daily for 5-7 days, then 2-4 mg daily until satisfactory disease control achieved. Maintenance: 2-6 mg once/wk.
Inj Multiple myeloma 0.4 mg/kg body wt repeated at appropriate intervals.
Ovarian adenocarcinoma 1 mg/kg body wt given at 4 wk intervals.
Malignant melanoma Upper extremity perfusion: 0.6-1 mg/kg body wt. Lower extremity perfusion: 0.8-1.5 mg/kg body wt.
Soft tissue sarcoma Upper extremity perfusion: 0.6-1 mg/kg body wt. Lower extremity perfusion: 1-1.4 mg/kg body wt.
Advanced neuroblastoma 100-240 mg/m
2 BSA.
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