View Acnotin overdosage for action to be taken in the event of an overdose.
Administration
Should be taken with food.
Contraindications
Pregnancy & lactation. Hepatic & renal insufficiency, hypervitaminosis A, hyperlipidaemia. Avoid blood donation by patients during & w/in 1 mth of cessation of treatment to women of childbearing potential.
Should only be prescribed by physicians who are experienced in the use of systemic retinoids, preferably dermatologists, & understand the risk of teratogenicity if isotretinoin is used during pregnancy. Perform baseline & periodic liver function test & fasting serum lipid level. History of depression. Avoid contraceptives containing an androgen progestational substance especially in the presence of gynaeco-endocrinological problems. Avoid dermabrasion & wax epilation. Frequent checking required for relevant laboratory parameters in high risk patients (w/ diabetes, obesity, alcoholism or disorders of lipid metabolism). Avoid sun exposure. Employ effective contraception starting 1 mth pre-treatment, during treatment, & for 1 mth post-treatment. Keep regular dental appointments. Use of sugarless candy or saliva substitute or melting ice in mouth may be necessary to lessen dental problems. May cause depression, psychosis & rarely, suicidal ideation, suicide attempts, suicide & aggressive &/or violent behaviors. Assess patients for symptoms of depression, mood disturbance, psychosis or aggression. Closely monitor patients for erythema multiforme & severe skin reactions; discontinue isotretinoin if warranted.
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