Adjunct in treatment-resistant depression
Adult: As L-tryptophan: 1 g tid. Max: 6 g daily.
Elderly: Dose reduction may be needed.
Elderly: Dose reduction may be needed.
Chỉ định và Liều dùng
Oral
Adjunct in treatment-resistant depression Adult: As L-tryptophan: 1 g tid. Max: 6 g daily.
Elderly: Dose reduction may be needed. |
Suy thận
Dose reduction may be needed.
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Suy gan
Dose reduction may be needed.
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Chống chỉ định
History of eosinophilia-myalgia syndrome associated with tryptophan treatment.
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Thận trọng
May affect ability to drive or operate machinery. Monitor for suicidal thoughts or clinical worsening of depression during initial treatment period. Renal or hepatic impairment. Elderly.
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Tác dụng không mong muốn
Nausea (take after food to minimise nausea), headache, lightheadedness, drowsiness, eosinophilia-myalgia syndrome.
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Quá liều
Symptoms: Drowsiness and vomiting. Management: Treatment is supportive.
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Tương tác
Increased risk of serotonin syndrome with SSRI. Possible decrease in levodopa plasma levels with tryptophan.
Potentially Fatal: Increased risk of severe behavioural and neurological toxicity with MAOI, start with lower initial dose of tryptophan if needed. |
Tác dụng
Description:
Mechanism of Action: Tryptophan is an essential amino acid which is the precursor of serotonin. It may be used as an adjunctive therapy in treatment-resistant depression. It is sometimes administered with pyridoxine and ascorbic acid. Due to its association with eosinophilia-myalgia syndrome, the use of tryptophan as dietary supplements (e.g. for insomnia) is limited or restricted. Pharmacokinetics: Absorption: Readily absorbed from GI tract. Distribution: Protein binding: Extensive, to plasma albumin. Metabolism: By liver to metabolites e.g. hydroxytryptophan and kynurenine derivatives. Excretion: Elimination half life (oral or IV L-tryptophan): 1-3 hr. |
Phân loại MIMS
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