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Chỉ định và Liều dùng
Oral
Irritable bowel syndrome Adult: 100-200 mg tid.
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Cách dùng
May be taken with or without food.
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Hướng dẫn pha thuốc
Reconstitute the granules in the provided bottle by adding water up to the designated mark then shake the bottle to mix. Refer to specific product guidelines for appropriate instructions on reconstitution.
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Thận trọng
Pregnancy and lactation.
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Tác dụng không mong muốn
Significant: CNS depression.
Nervous system disorders: Presyncope/syncope. Skin and subcutaneous tissue disorders: Rash. Psychiatric disorders: Mood change. |
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Thông tin tư vấn bệnh nhân
This drug may impair physical and mental abilities, if affected, do not drive or operate machinery.
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Tác dụng
Description:
Mechanism of Action: Trimebutine is a gastrointestinal motility modifier. It promotes intestinal motility by triggering phase-III waves produced by the migrating motor complex, it also inhibits motility in the occurrence of prior stimulation. Pharmacokinetics: Absorption: Rapidly absorbed from the gastrointestinal tract. Time to peak plasma concentration: 1-2 hours. Excretion: Mainly via urine (70%); faeces (5-12%). Elimination half-life: Approx 10-12 hours. |
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Đặc tính
 Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 5573, Trimebutine. https://pubchem.ncbi.nlm.nih.gov/compound/Trimebutine. Accessed July 28, 2021. |
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Bảo quản
Store below 30°C.
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Phân loại MIMS
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Phân loại ATC
A03AA05 - trimebutine ; Belongs to the class of synthetic anticholinergics, esters with tertiary amino group. Used in the treatment of functional bowel disorders.
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Tài liệu tham khảo
Anon. Trimebutine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 09/07/2021. Buckingham R (ed). Trimebutine Maleate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 09/07/2021.
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