Thông tin thuốc của Trientine

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Thông tin thuốc gốc

Chỉ định và Liều dùng

Oral
Wilson's disease

Adult: In patients who are intolerant of penicillamine: As trientine dihydrochloride cap: 1,200-2,400 mg daily in 2-4 divided doses. Alternatively, 750-1,250 mg daily in 2-4 divided doses (Max: 2,000 mg daily). As trientine tetrahydrochloride tab: 450-975 mg daily in 2-4 divided doses. Initiate at the lowest dose in the range and adjust according to patient response and serum copper level. Dosage recommendations may vary among countries and individual products (refer to specific product guidelines).
Elderly: As trientine dihydrochloride cap: May initiate at the lower end of the dosing range.
Child: In patients who are intolerant of penicillamine: ≥5 years As trientine dihydrochloride cap: Initially, 20 mg/kg daily rounded off to the nearest 250 mg cap given in 2-3 divided doses. Alternatively, 500-750 mg daily in divided doses (Max: 1,500 mg daily). As trientine tetrahydrochloride tab: 225-600 mg daily in 2-4 divided doses. Adjust dose according to patient response and serum copper level. Dosage recommendations may vary among countries and individual products (refer to specific product guidelines).

Cách dùng

Should be taken on an empty stomach. Take at least 1 hr before or 2 hr after meals, & at least 1 hr before or after any other medicine, food or milk.

Thận trọng

Patient with pre-existing neurological symptoms. Renal and hepatic impairment. Children and elderly. Pregnancy and lactation.

Tác dụng không mong muốn

Significant: Fe deficiency anaemia; copper deficiency, sideroblastic anaemia; neurologic worsening; SLE.
Gastrointestinal disorders: Nausea, gastritis, duodenitis, colitis (including severe colitis).
Musculoskeletal and connective tissue disorders: Muscle spasm, myasthenia gravis, dystonia.
Skin and subcutaneous tissue disorders: Rash, pruritus, erythema, urticaria.

Phân loại thai kỳ (US FDA)

PO: C

Thông tin tư vấn bệnh nhân

Do not switch between brands or dosage forms unless instructed by your doctor, as different brands or dosage forms may contain different amounts of trientine base.

Chỉ số theo dõi

Monitor for fever and skin changes during the 1st month of therapy; changes in neurological status; evidence of Fe deficiency anaemia (particularly in women). Perform 24-hour urinary copper assessment periodically (every 6-12 months). Monitor serum non-ceruloplasmin bound copper, LFTs, CBC, INR, urinalysis.

Tương tác

Trientine and Fe may each inhibit the absorption of the other.

Tương tác với thức ăn

May result in chelation when given with food, dairy products, or other sources of polyvalent cations.

Tác dụng

Description:
Mechanism of Action: Trientine is an oral chelating agent. It is used to eliminate absorbed copper from the body through the formation of a stable complex that is eventually excreted from the kidney. It may also inhibit copper absorption by chelation in the intestinal tract.
Synonym: trientine dihydrochloride: trientine hydrochloride.
Pharmacokinetics:
Absorption: Rapidly but poorly absorbed from the gastrointestinal tract. Time to peak plasma concentration: 1.25-2 hours.
Distribution: Volume of distribution: 393 L (central); 252 L (peripheral).
Metabolism: Extensively metabolised via acetylation into major metabolites, N₁-acetyltriethylenetetramine and N₁, N₁₀-diacetyltriethylenetetramine.
Excretion: Via urine (1% as unchanged drug; 8% as metabolite). Elimination half-life: 2-4 hours.

Đặc tính

Chemical Structure Image — **Trientine**

Bảo quản

Cap: Store between 2-8°C. Do not freeze. Storage recommendations may vary among countries and individual products. Refer to specific product guidelines.

Phân loại MIMS

Thuốc giải độc & khử độc

Phân loại ATC

A16AX12 - trientine ; Belongs to the class of various alimentary tract and metabolism products.

Tài liệu tham khảo

Anon. Trientine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 18/12/2020.

Buckingham R (ed). Trientine Dihydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 18/12/2020.

Cuprior 150 mg Film-Coated Tablets (Orphalan). European Medicines Agency [online]. Accessed 19/03/2021.

Joint Formulary Committee. Trientine Dihydrochloride. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 18/12/2020.

Syprine Capsule (Bausch Health US LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 19/03/2021.

Trientine Dihydrochloride Capsules 300 mg (Univar Solutions BV). MHRA. https://products.mhra.gov.uk. Accessed 18/12/2020.

Trientine Dihydrochloride Tillomed 250 mg Capsules, Hard (Tillomed Laboratories Ltd). MHRA. https://products.mhra.gov.uk. Accessed 18/12/2020.

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