|
Chỉ định và Liều dùng
Topical/Cutaneous
Nail fungal infections Adult: As 28% soln: Apply to the affected nails and immediately surrounding skin 12 hrly for up to 6-12 mth. Elderly: Same as adult dose. Child: Same as adult dose. Vaginal Vaginal candidiasis Adult: As 6.5% oint: Insert 1 applicatorful intravaginally at bedtime as single dose.
|
|
Chống chỉ định
Hypersensitivity.
|
|
Thận trọng
Self-medication in patient w/ DM, HIV infection. Girls <12 yr (vag). Pregnancy and lactation.
|
|
Tác dụng không mong muốn
Vulvovaginal burning and irritation, vaginitis, pruritus, vulvovaginal disorder and desquamation, vag pain, vulvar oedema or swelling, vag discharge, vag dryness, rash and dyspareunia; headache, abdominal pain, dysuria, nocturia, pharyngitis, rhinitis; transient, minor increases in LDH, AST (SGOT) and ALT (SGPT). Contact dermatitis, burning, irritation (topical).
|
|
Thông tin tư vấn bệnh nhân
Vag: Avoid sexual intercourse. Condoms and diaphragms may be damaged and fail to prevent pregnancy or STD, may resume usage 3 days after treatment. Avoid using tampons, douches, spermicides or other vag products.
|
|
Tác dụng
Description:
Mechanism of Action: Tioconazole, a synthetic azole antifungal, interferes w/ synthesis of ergosterol which is needed for fungal cell membrane synthesis. Onset: Intravaginal: Some improvement w/in 24 hr; complete relief w/in 7 days. Pharmacokinetics: Absorption: Intravaginal: Absorbed systemically (small amounts). Distribution: Persists in vag fluid for 24-72 hr. Excretion: Via urine and faeces. |
|
Đặc tính
 Source: National Center for Biotechnology Information. PubChem Database. Tioconazole, CID=5482, https://pubchem.ncbi.nlm.nih.gov/compound/Tioconazole (accessed on Jan. 23, 2020) |
|
Bảo quản
Store between 20-25°C.
|
|
Phân loại MIMS
|
|
Tài liệu tham khảo
Anon. Tioconazole. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 18/07/2014. Buckingham R (ed). Tioconazole. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 13/08/2014. McEvoy GK, Snow EK, Miller J et al (eds). Tioconazole (Vaginal). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 18/07/2014. Tioconazole 1-1 Dose Treatment Ointment (Rite Aid Corporation). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 18/07/2014. Wickersham RM. Tioconazole – Vaginal. Facts and Comparisons [online]. St. Louis, MO. Wolters Kluwer Clinical Drug Information, Inc. https://www.wolterskluwercdi.com/facts-comparisons-online/. Accessed 18/07/2014.
|
Đăng xuất
