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Chỉ định và Liều dùng
Topical/Cutaneous
Psoriasis vulgaris Adult: As 4 mcg/g lotion or ointment: Apply sparingly onto affected areas once daily, preferably at bedtime. Max: 10 g of ointment or 10 mL of lotion daily; 280 mcg weekly (e.g. 30 mL lotion + 40 g ointment). Treatment duration depends on severity of lesions; may be used continuously or intermittently for up to 8 weeks (lotion), or up to 18 months (ointment).
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Chống chỉ định
Hypersensitivity. Severe cardiac disease, hypercalcaemia, Ca metabolism disorders, psoriasis punctata or psoriasis pustulosa. Severe renal and hepatic impairment.
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Thận trọng
Combined treatment with UV radiation. Elderly. Pregnancy and lactation.
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Tác dụng không mong muốn
Significant: Hypercalcaemia.
Immune system disorders: Hypersensitivity reactions including swelling, oedema, face oedema. Skin and subcutaneous tissue disorders: Itching, rash (erythematous, macular, papular, vesicular), skin irritation (e.g. burning, erythema), worsening of psoriasis. |
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Thông tin tư vấn bệnh nhân
Avoid contact with eyes. Do not smoke or go near naked flames.
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Chỉ số theo dõi
Monitor Ca (serum and corrected levels), albumin; vitamin D (in patients receiving vitamin D therapy); renal function (as clinically indicated).
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Tương tác
Increased efficacy and shortened period of UVB radiation. May enhance toxic effects of other vitamin D analogues. Increased hypercalcaemic effect with thiazide and thiazide-like diuretics.
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Tác dụng
Description:
Mechanism of Action: Tacalcitol, a vitamin D3 derivative, binds to keratinocyte vitamin D3 receptor, thus inhibiting keratinocyte hyperproliferation and inducing differentiation of these cells. Pharmacokinetics: Absorption: <0.5% absorbed through psoriatic skin. Distribution: Plasma protein binding: Completely bound, mainly to vitamin D binding protein. Metabolism: Metabolised to 1-α, 24, 25 (OH)3 vitamin D3 (primary). Excretion: Via urine. |
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Đặc tính
 Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 5283734, Tacalcitol. https://pubchem.ncbi.nlm.nih.gov/compound/Tacalcitol. Accessed Nov. 21, 2023. |
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Bảo quản
Store below 25°C.
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Phân loại MIMS
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Phân loại ATC
D05AX04 - tacalcitol ; Belongs to the class of other antipsoriatics for topical use.
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Tài liệu tham khảo
Anon. Tacalcitol. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 18/09/2023. Buckingham R (ed). Tacalcitol. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 18/09/2023. Curatoderm 4 mcg/g Ointment (Almirall Hermal GmbH). MHRA. https://products.mhra.gov.uk. Accessed 18/09/2023. Curatoderm 4 micrograms/g Lotion (Almirall Hermal GmbH). MHRA. https://products.mhra.gov.uk. Accessed 18/09/2023. Joint Formulary Committee. Tacalcitol. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 18/09/2023.
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