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Chỉ định và Liều dùng
Intramuscular
Anaemia, Breast cancer in postmenopausal women, Catabolic disorders, Osteopetrosis Adult: 50 mg every 2-3 wk. Oral Vascular manifestations of Behcet's syndrome Adult: 10 mg daily. Oral Hereditary angioedema Adult: Initially, 2.5-10 mg daily, reduced according to response. Maintenance: 2 mg daily or on alternate days or 2.5 mg 3 times wkly.
Child: <6 yr: 1 mg daily; 6-12 yr: Up to 2 mg daily. |
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Chống chỉ định
Pregnancy and lactation; carcinoma of prostate or breast in men, hypercalcaemia, hypercalciuria, porphyria, severe hepatic impairment.
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Thận trọng
Patients with cardiac, renal or hepatic disease, epilepsy or DM. Children, elderly. Monitor liver function, haematocrit and haemoglobin concentrations. Not recommended for treatment of hereditary angioedema in premenopausal women.
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Tác dụng không mong muốn
Peliosis hepatis, premature epiphyseal closure, cholestatic jaundice, virilism, impotence, priapism, testicular atrophy, gynaecomastia, prostatic hyperplasia, decreased libido, hirsutism, menstrual irregularities; oedema, acne.
Potentially Fatal: Hepatic necrosis, hepatocellular carcinoma. |
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Tương tác
Enhances activity of insulin, sulfonylureas, levothyroxine and anticoagulants e.g. warfarin. May cause resistance to the effects of neuromuscular blockers.
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Ảnh hưởng đến kết quả xét nghiệm
May interfere with laboratory tests for glucose tolerance and thyroid function.
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Tác dụng
Description:
Mechanism of Action: Stanozolol is a structural analogue of testosterone which increases collagen production and decreases the anti-anabolic action of cortisone. It is also reported to reduce fibrin deposition. It corrects the formation of kinin or kinin-like factors which may be associated with oedema and swelling seen in hereditary angioedema. Pharmacokinetics: Metabolism: Hepatic. Excretion: Urine (90%), faeces (6%). |
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Phân loại MIMS
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Đăng xuất
