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Chỉ định và Liều dùng
Parenteral
Growth hormone deficiency Child: 4 units 3 times/wk. May be given via SC or IM inj.
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Chống chỉ định
Active neoplasms or intracranial lesions; closed epiphyses. Pregnancy. Proliferative or preproliferative diabetic retinopathy. Patients with Prader-Willi syndrome who are severely obese or have severe respiratory impairment.
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Thận trọng
DM (adjustment of antidiabetic therapy may be necessary); acute catabolic states (severe burns or critically ill). Lactation. Discontinue treatment if there is evidence of tumour growth. Monitoring during therapy is recommended in patients with scoliosis due to risk of progression of scoliosis that can occur with rapid growth. Hypothyroidism may develop during therapy causing suboptimal response.
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Tác dụng không mong muốn
Redness, itching, lumps or lipoatrophy at inj site. Headache, muscle and joint pain, benign intracranial hypertension. May increase risk of ear disorders in patients with Turner's syndrome.
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Parenteral: C
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Tương tác
Growth-promoting effect may be inhibited by corticosteroids.
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Tác dụng
Description:
Mechanism of Action: Somatrem is an analogue of somatropin containing an additional (methionyl) amino acid residue. It is commonly used in children with open epiphyses for the treatment of short stature due to deficiency of growth hormone. May also be used in adults with confirmed growth hormone deficiency or management of wasting or cachexia associated with AIDS. |
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Phân loại MIMS
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Đăng xuất
