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Chỉ định và Liều dùng
Oral
Ascariasis Adult: Doses are expressed as pyrantel base. Alternative agent: Usual dose: 10-11 mg/kg as a single dose. Max: 1,000 mg/dose. Oral Enterobiasis Adult: Doses are expressed as pyrantel base. Usual dose: 10-11 mg/kg as a single dose, repeated after 2 weeks to prevent reinfection. Max: 1,000 mg/dose.
Child: ≥2 years Same as adult dose. |
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Cách dùng
May be taken with or without food.
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Chống chỉ định
Hypersensitivity.
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Thận trọng
Patient with severe malnutrition, dehydration or anaemia. Hepatic impairment. Children. Pregnancy and lactation.
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Tác dụng không mong muốn
Gastrointestinal disorders: Nausea, vomiting, abdominal pain or cramps, diarrhoea.
Investigations: Transient increase in liver enzymes, particularly AST. Metabolism and nutrition disorders: Anorexia. Nervous system disorders: Dizziness, headache, drowsiness. Skin and subcutaneous tissue disorders: Rash. |
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Chỉ số theo dõi
Monitor stool for the presence of worms, eggs, and occult blood.
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Tương tác
May antagonise the effects of piperazine, and vice versa.
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Tác dụng
Description:
Mechanism of Action: Pyrantel is a pyrimidine-derivative anthelmintic agent that acts as a depolarising neuromuscular blocker. It provides its anthelmintic effect by releasing acetylcholine and inhibiting cholinesterase, thereby stimulating the ganglionic (nicotinic) receptors of susceptible helminths. This activity results in the paralysis and detachment of helminths that can be expelled from the gastrointestinal tract via normal peristalsis. Pharmacokinetics: Absorption: Poorly and incompletely absorbed from the gastrointestinal tract. Time to peak plasma concentration: 1-3 hours. Metabolism: Partially metabolised in the liver. Excretion: Via faeces (<50% as unchanged drug); urine (approx 7% as unchanged drug and metabolites). |
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Đặc tính
 Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 708857, Pyrantel. https://pubchem.ncbi.nlm.nih.gov/compound/Pyrantel. Accessed Aug. 26, 2021. |
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Bảo quản
Store between 15-30°C.
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Phân loại MIMS
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Phân loại ATC
P02CC01 - pyrantel ; Belongs to the class of tetrahydropyrimidine derivative agents. Used as antinematodal.
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Tài liệu tham khảo
Anon. Pyrantel Pamoate. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 06/08/2021. Anon. Pyrantel. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 06/08/2021. Buckingham R (ed). Pyrantel Embonate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/08/2021. Combantrin (Johnson & Johnson [Phils.] Inc.). MIMS Philippines. http://www.mims.com/philippines. Accessed 06/08/2021. Pyrantel Pamoate Suspension (Jefferson Labs). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 06/08/2021. Pyrantel Pamoate Tablet (ProMex LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 06/08/2021. Pyrantel. Gold Standard Drug Database in ClinicalKey [online]. Elsevier Inc. https://www.clinicalkey.com. Accessed 06/08/2021. Pyrapam (General Drugs House Co Ltd). MIMS Thailand. http://www.mims.com/thailand. Accessed 06/08/2021.
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