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Chỉ định và Liều dùng
Oral
Chronic idiopathic constipation Adult: 2 mg once daily.
Elderly: Initially, 1 mg once daily, may increase to 2 mg once daily if necessary. |
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Suy thận
Severe (GFR <30 mL/min/1.73 m2): 1 mg once daily. Patient on dialysis: Contraindicated.
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Suy gan
Severe (Child-Pugh Class C): Initially, 1 mg once daily, may increase to 2 mg once daily if necessary.
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Cách dùng
May be taken with or without food.
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Chống chỉ định
Intestinal obstruction or perforation, obstructive ileus, active severe inflammatory bowel conditions (e.g. Crohn’s disease, toxic megacolon/megarectum, and ulcerative colitis). Renal impairment requiring dialysis. Pregnancy and lactation.
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Thận trọng
Patient w/ history of arrhythmias or ischaemic CV disease, severe and unstable concomitant disease (e.g. cancer, AIDS, neurological or psychiatric, pulmonary, IDDM or other endocrine disroders). Severe hepatic (Child-Pugh Class C) and renal (GFR <30 mL/min/1.73 m2) impairment. Elderly.
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Tác dụng không mong muốn
Nervous: Headache, dizziness, fatigue, malaise, tremors.
CV: Palpitations. GI: Nausea, abdominal pain and distention, diarrhoea, vomiting, flatulence, dyspepsia, anorexia, rectal bleeding, gastroenteritis. Genitourinary: Polyuria, pollakiuria. Musculoskeletal: Muscle spasm. Others: Fever. |
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Thông tin tư vấn bệnh nhân
This drug may cause dizziness and fatigue, if affected, do not drive or operate machinery.
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Chỉ số theo dõi
Monitor bowel movement frequency.
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Tương tác
May decrease serum concentration of contraceptives (i.e. oestrogens, progestins). May enhance adverse effect of levosulpiride. Increased serum concentration w/ P-glycoprotein/ABCB1 inhibitors. Reduced effect w/ atropine-like substance.
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Tác dụng
Description:
Mechanism of Action: Prucalopride is a selective 5-HT4 receptor agonist w/ prokinetic effect. It stimulates peristaltic reflex, intestinal secretions, and GI motility. Pharmacokinetics: Absorption: Rapidly absorbed from the GI tract. Absolute bioavailability: >90%. Time to peak plasma concentration: 2-3 hr. Distribution: Extensively distributed; enters breast milk. Volume of distribution: 567 L. Plasma protein binding: Approx 30%. Metabolism: Metabolised slowly in the liver. Excretion: Via urine (approx 60-65% as unchanged drug); faeces (approx 5% as unchanged drug). Terminal elimination half-life: Approx 24 hr. |
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Đặc tính
 Source: National Center for Biotechnology Information. PubChem Database. Prucalopride, CID=3052762, https://pubchem.ncbi.nlm.nih.gov/compound/Prucalopride (accessed on Jan. 23, 2020) |
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Bảo quản
Store between 15-30°C.
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Phân loại ATC
A06AX05 - prucalopride ; Belongs to the class of other laxatives.
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Tài liệu tham khảo
Anon. Prucalopride. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 03/04/2017. Buckingham R (ed). Prucalopride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 03/04/2017. Joint Formulary Committee. Prucalopride. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 03/04/2017.
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