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Chỉ định và Liều dùng
Ophthalmic
Surface anaesthesia Adult: As 0.5% soln: For tonometry: Instil 1-2 drops immediately before measurement. For removal of foreign body or suture: Instil 1-2 drops 2 or 3 min prior to procedure or every 5-10 min for 1-3 doses. For short corneal and conjunctival procedure: Instil 1 drop every 5-10 min for 5-7 doses.
Child: Same as adult dose. |
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Chống chỉ định
Preterm neonates.
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Thận trọng
Patients w/ known allergies, cardiac disease, hyperthyroidism, inflamed eye. Prolonged use. Pregnancy and lactation.
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Tác dụng không mong muốn
Significant: Permanent corneal opacification w/ vision loss (prolonged use).
Ophthalmologic: Burning sensation, redness, cycloplegia, mydriasis, stinging, conjunctival hemorrhage or hyperaemia, corneal erosion. Rarely, hyperallergic corneal reaction (e.g. acute, intense and diffuse epithelial keratitis; a grey ground-glass appearance; exfoliation of skin; corneal filaments, iritis w/ descemetitis). Dermatologic: Allergic contact dermatitis. |
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Ophth: C
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Thông tin tư vấn bệnh nhân
This drug may cause transient blurring of vision, if affected, do not drive or operate machinery. Avoid touching or rubbing of eye(s) until anaesthesia has worn off.
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Tác dụng
Description:
Mechanism of Action: Proxymetacaine, a meta-aminobenzoic acid ester, decreases Na ion permeability by reversibly blocking the initiation and conduction of impulse at the nerve cell membrane. Onset: W/in 20 seconds. Duration: Approx 10-20 min. Pharmacokinetics: Absorption: Readily absorbed into the systemic circulation. Metabolism: Undergoes hydrolysis by plasma esterases; also subject to hepatic metabolism. |
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Đặc tính
 Source: National Center for Biotechnology Information. PubChem Database. Proparacaine, CID=4935, https://pubchem.ncbi.nlm.nih.gov/compound/Proparacaine (accessed on Jan. 23, 2020) |
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Bảo quản
Store between 2-8°C. Do not freeze. Protect from light.
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Phân loại MIMS
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Phân loại ATC
S01HA04 - proxymetacaine ; Belongs to the class of local ophthalmologic anesthetics.
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Tài liệu tham khảo
Anon. Proparacaine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 04/04/2017 . Buckingham R (ed). Proxymetacaine Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 04/04/2017 . Joint Formulary Committee. Proxymetacaine Hydrochloride. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 04/04/2017 . McEvoy GK, Snow EK, Miller J et al (eds). Proparacaine Hydrochloride (EENT). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 04/04/2017 . Proparacaine Hydrochloride Solution/Drops (Sandoz Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 04/04/2017 .
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