Susceptible infections
Adult: 2-4 g/day in divided doses.
Chỉ định và Liều dùng
Oral
Susceptible infections Adult: 2-4 g/day in divided doses.
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Chống chỉ định
Hypersensitivity.
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Thận trọng
Pseudomembranous colitis.
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Tác dụng không mong muốn
GI disturbances; hypersensitivity reactions.
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Tương tác
May increase serum levels of ciclosporin.
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Tác dụng
Description:
Mechanism of Action: Pristinamycin is a streptogramin antibacterial which reversibly binds to 50s subunit of bacterial ribosome blocking the transpeptidation and inhibiting protein synthesis of susceptible bacteria thus inhibiting cell growth. Its spectrum of activity includes many gm+ve and some gm-ve bacteria, as well as mycoplasmas, spirochetes, chlamydias and rickettsias. It is active against staphylococci and some streptococci. N. gonorrheae and H. influenzae are sensitive. There is cross-resistance with macrolides and lincosamides. |
Phân loại MIMS
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