Adult: As 0.1% cream or ointment: Apply a thin film and rub gently onto the affected area(s) bid. Discontinue therapy when control is achieved; reassess treatment if there is no improvement within 2 weeks. As 0.25% cream: Apply thinly onto affected area(s) 1-2 times daily. Child: As 0.1% cream: ≥1 year Apply a thin film and rub gently onto the affected area(s) bid. Max treatment duration: 3 weeks. As 0.1% ointment: ≥10 years Same as adult.
Chống chỉ định
As 0.25% cream: Skin manifestations resulting from chickenpox, syphilis, TB, vaccinations, or perioral dermatitis.
Thận trọng
Avoid application on the face, groin area, underarms or open wounds. Do not cover with occlusive dressings. Avoid contact with eyes; latex-containing products (e.g. condoms, diaphragm). Do not apply intravaginally. Children. Pregnancy and lactation.
Tác dụng không mong muốn
Significant: Hypercortisolism or HPA axis suppression (particularly at high doses for prolonged periods or in younger children), allergic contact dermatitis, fungal or bacterial superinfection, Kaposi sarcoma (prolonged use), hyperglycaemia or glycosuria. Skin and subcutaneous tissue disorders: Burning, pruritus, drying, scaling, cracking, pain, irritant dermatitis, skin atrophy, urticaria, rash, oedema, paraesthesia.
Monitor growth (in children). If HPA axis suppression is suspected, evaluate patient using the ACTH stimulation, plasma cortisol, or urinary free cortisol test.
Tác dụng
Description: Mechanism of Action: Prednicarbate is a synthetic, nonhalogenated, medium-potency topical corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties. The exact mechanism for its anti-inflammatory activity is unclear; however, corticosteroids are thought to depress the formation, release, and activity of endogenous chemical mediators of inflammation such as kinins, histamine, liposomal enzymes, and prostaglandins through induction of phospholipase A2 inhibitory proteins (collectively called lipocortins) and sequential inhibition of the release of arachidonic acid. Pharmacokinetics: Absorption: Absorbed percutaneously.
Đặc tính
Prednicarbate Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 6714002, Prednicarbate. https://pubchem.ncbi.nlm.nih.gov/compound/Prednicarbate. Accessed Feb. 27, 2023.
Bảo quản
Cream: Store between 5-25°C. Ointment: Store between 20-25°C.
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