Piracetam


Thông tin thuốc gốc
Chỉ định và Liều dùng
Intravenous
Vertigo
Adult: In cases when oral administration is not possible (e.g. difficulty swallowing, unconsciousness): 2.4-4.8 g daily in 2-3 divided doses via inj over several minutes or continuous infusion over 24-hour period.

Intravenous
Cortical myoclonus
Adult: In cases when oral administration is not possible (e.g. difficulty swallowing, unconsciousness): As monotherapy or in combination with other anti-myoclonic drugs: Initially, 7.2 g daily in 2 or 3 divided doses, then increased by 4.8 g every 3-4 days. Max: 24 g daily in 2-3 divided doses. Doses are given via inj over several minutes or continuous infusion over 24-hour period. Continue treatment for as long as the original cerebral disease persists. May consider dosage reduction or gradual discontinuation of therapy every 6 months if symptoms are controlled. Reduce dose by 1.2 g every 2 days (every 3-4 days for Lance-Adams syndrome). Treatment recommendations may vary among countries and individual products (refer to specific product guideline).

Intravenous
Cognitive impairment
Adult: In cases when oral administration is not possible (e.g. difficulty swallowing, unconsciousness): Dose range: 1.2-4.8 g daily in 2-4 divided doses via inj over several minutes or continuous infusion over 24-hour period. Treatment may be initiated at 4.8 g daily depending on the severity of symptoms. Dosage recommendations may vary among countries and individual products (refer to specific product guideline).

Oral
Vertigo
Adult: Dose range: 2.4-4.8 g daily in 2-3 divided doses.

Oral
Cortical myoclonus
Adult: As monotherapy or in combination with other anti-myoclonic drugs: Initially, 7.2 g daily in 2 or 3 divided doses, then increased by 4.8 g every 3-4 days. Max: 24 g daily in 2-3 divided doses. Continue treatment for as long as the original cerebral disease persists. Once symptoms are controlled, consider dosage reduction or gradual discontinuation of therapy every 6 months. Dose reduction may be done by 1.2 g every 2 days (every 3-4 days for Lance-Adams syndrome). Treatment recommendations may vary among countries and individual products (refer to specific product guideline).

Oral
Cognitive impairment
Adult: Dose range: 1.2-4.8 g daily in 2-4 divided doses. Treatment may be initiated at 4.8 g daily depending on the severity of symptoms. Dosage recommendations may vary among countries and individual products (refer to specific product guideline).

Oral
Dyslexia
Child: ≥8-13 years In combination with appropriate measures (e.g. speech therapy): As 200 mg/mL oral solution or 800 mg tab: 3.2 g daily in 2 divided doses. Treatment recommendations may vary among countries and individual products (refer to specific product guideline).
Suy thận
CrCl (mL/min) Dosage
<20 or ESRD Contraindicated.
20-29 1/6 of the usual daily dose once daily.
30-49
1/3 of the usual daily dose in 2 divided doses.
50-79
2/3 of the usual daily dose in 2-3 divided doses.
Cách dùng
May be taken with or without food. Take w/ a glass of water or soft drink to mask bitter taste.
Chống chỉ định
Cerebral haemorrhage, Huntington's chorea. ESRD or severe renal impairment (CrCl <20 mL/min).
Thận trọng
Patient with severe haemorrhage, increased risk of bleeding (e.g. gastrointestinal ulcer), underlying haemostatic disorder, history of haemorrhagic cerebrovascular accident (CVA). Patient undergoing major surgery including dental surgery or receiving anticoagulants or antiplatelet drugs (including low dose aspirin). Avoid abrupt withdrawal. Renal impairment. Children and elderly. Pregnancy and lactation.
Tác dụng không mong muốn
Significant: Bleeding disorder, CNS effects (e.g. impaired coordination, weakness, drowsiness).
General disorders and administration site conditions: Rarely, pyrexia, inj site pain (IV).
Investigations: Weight gain.
Nervous system disorders: Hyperkinesia.
Psychiatric disorders: Nervousness, depression.
Vascular disorders: Rarely, thrombophlebitis, hypotension (IV).
Thông tin tư vấn bệnh nhân
This drug may cause drowsiness, weakness and impaired coordination, if affected, do not drive or operate machinery.
Chỉ số theo dõi
Monitor renal function.
Tương tác
Concomitant use with thyroid hormones may cause confusion, irritability and sleep disorder. May increase the effects of anticoagulants (e.g. acenocoumarol) or antiplatelet agents (e.g. aspirin).
Tác dụng
Description:
Mechanism of Action: Piracetam is a nootropic that acts on the CNS. Its exact mechanism in reducing symptoms of cortical myoclonus is not yet fully elucidated however, it is suggested to be due to its GABA-mimetic effects. It is believed to exert neuronal effect by protecting the cerebral cortex and restoring cognitive abilities after various cerebral trauma (e.g. hypoxia, intoxications, electroconvulsive therapy). Additionally, it has vascular effects on thrombocytes, erythrocytes and blood vessel walls by enhancing the erythrocyte deformability, decreasing the aggregability of thrombocytes, and reducing capillary vasospasm and erythrocyte adhesion to the blood vessel walls.
Pharmacokinetics:
Absorption: Rapidly and almost completely absorbed from the gastrointestinal tract. Bioavailability: Approx 100% (oral). Time to peak plasma concentration: 1-1.5 hours (oral).
Distribution: Distributed to all tissues except adipose tissues; penetrates the membranes of isolated RBCs. Crosses the placenta and blood brain barrier; enters breast milk. Volume of distribution: Approx 0.7 L/kg.
Metabolism: Not significantly metabolised.
Excretion: Via urine (80-100% as unchanged drug). Plasma elimination half-life: Approx 5 hours.
Đặc tính

Chemical Structure Image
Piracetam

Source: National Center for Biotechnology Information. PubChem Database. Piracetam, CID=4843, https://pubchem.ncbi.nlm.nih.gov/compound/Piracetam (accessed on Jan. 22, 2020)

Bảo quản
Store between 15-30°C.
Phân loại MIMS
Thuốc hướng thần kinh & thuốc bổ thần kinh
Phân loại ATC
N06BX03 - piracetam ; Belongs to the class of other psychostimulants and nootropics.
Tài liệu tham khảo
Anon. Piracetam. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 07/05/2021.

Buckingham R (ed). Piracetam. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 07/05/2021.

Ceretam Film-Coated Tablet; Oral Solution 20% w/v (Av Manufacturing Sdn Bhd). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 14/05/2021.

Joint Formulary Committee. Piracetam. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 07/05/2021.

Nootropil (GlaxoSmithKline Limited). MIMS Hong Kong. http://www.mims.com/hongkong. Accessed 14/05/2021.

Nootropil (GlaxoSmithKline Pharmaceutical Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 14/05/2021.

Nootropil (GlaxoSmithKline Philippines Inc). MIMS Philippines. http://www.mims.com/philippines. Accessed 14/05/2021.

Nootropil 1,200 mg Film-Coated Tablets (UCB Pharma Ltd.). MHRA. https://products.mhra.gov.uk. Accessed 07/05/2021.

Nootropil 12 g/60 mL Solution for Infusion (GlaxoSmithKline Limited). MIMS Hong Kong. http://www.mims.com/hongkong. Accessed 14/05/2021.

Nootropil 33% Oral Solution (UCB Pharma Ltd.). MHRA. https://products.mhra.gov.uk. Accessed 07/05/2021.

Nootropil 800 mg Film-Coated Tablets (UCB Pharma Ltd.). MHRA. https://products.mhra.gov.uk. Accessed 07/05/2021.

Thông báo miễn trừ trách nhiệm: Thông tin này được MIMS biên soạn một cách độc lập dựa trên thông tin của Piracetam từ nhiều nguồn tài liệu tham khảo và được cung cấp chỉ cho mục đích tham khảo. Việc sử dụng điều trị và thông tin kê toa có thể khác nhau giữa các quốc gia. Vui lòng tham khảo thông tin sản phẩm trong MIMS để biết thông tin kê toa cụ thể đã qua phê duyệt ở quốc gia đó. Mặc dù đã rất nỗ lực để đảm bảo nội dung được chính xác nhưng MIMS sẽ không chịu trách nhiệm hoặc nghĩa vụ pháp lý cho bất kỳ yêu cầu bồi thường hay thiệt hại nào phát sinh do việc sử dụng hoặc sử dụng sai các thông tin ở đây, về nội dung thông tin hoặc về sự thiếu sót thông tin, hoặc về thông tin khác. © 2024 MIMS. Bản quyền thuộc về MIMS. Phát triển bởi MIMS.com
XEM THÊM
LESS
  • Alopia
  • Bretam
  • Cadipira
  • Cerefort
  • Ceretrop
  • Ceretrop 800
  • Cetam Caps
  • Ceteco Cenpira
  • Cirbrain
  • Chunggei Piracetam
  • Daeshinpiram
  • Diorophyl
  • Domiject
  • Dorocetam
  • Enpir-800
  • Fepinram
  • Hasancetam
  • Ikopir-800
  • Jeil p-tam
  • Knowful
  • Kwang Myung Piracetam
  • Medotam
  • Melanax
  • Memoril
  • Memotropil
  • Naatrapyl 1g/3g
  • Neni 800
  • Neurocetam
  • Neurofit
  • Neuropyl
  • Neu-Stam
  • Newsetam
  • Nootripam
  • Nootryl
  • Normacetam
  • Novadril
  • Nudipyl
  • Onbrain
  • P-Cet
  • Picencap Capsule
  • Picentab
  • Piracefti
  • Piracetam 400 DHG
  • Piracetam 800 (Hasan)
  • Piracetam 800 DHG
  • Piracetam Alpha Pharm
  • Piracetam Fine
  • Piracetam Medica Korea
  • Piracetam Mediplantex
  • Piracetam Polpharma
  • Piracetam Pharbaco
  • Piracetam Shandong
  • Piracetam Stada Pymepharco
  • Piracetam Tsinghua
  • Piracetam TV Pharm
  • Piracetam Thephaco
  • Piracetam Vidipha
  • Piracetam-Egis
  • Pirahexal 800
  • Piratrof
  • Pirimas
  • Pracet
  • Pracetam
  • P-Tam
  • Philsetam
  • Rataprome
  • Remact
  • Retento
  • Seoba
  • Setam
  • Soultam
  • Stimind
  • Tarvicetam
  • Toruxin
  • Ucetam
  • Vipicetam 800
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in