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Chỉ định và Liều dùng
Oral
Anxiety Adult: 10 mg daily in 2 divided doses; may increase to 20 mg daily in severe cases.
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Cách dùng
May be taken with or without food.
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Chống chỉ định
Myasthenia gravis, acute narrow-angle glaucoma. Pregnancy.
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Thận trọng
Patient with CV disease, blood dyscrasias. Hepatic impairment.
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Tác dụng không mong muốn
Blood and lymphatic system disorders: Rarely, bone marrow depression.
Cardiac disorders: Palpitations, tachycardia. Gastrointestinal disorders: Gastrointestinal disorders. Hepatobiliary disorders: Rarely, liver damage. Musculoskeletal and connective tissue disorders: Muscle weakness. Nervous system disorders: Ataxia, dizziness, drowsiness. Psychiatric disorders: Confusion. Skin and subcutaneous tissue disorders: Rash. |
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Tương tác
Enhances the sedative effects of other CNS depressant drugs (e.g. opioids, sedating antihistamines, barbiturates).
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Tương tác với thức ăn
Increases the CNS depressant effects of alcohol.
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Tác dụng
Description:
Mechanism of Action: Pinazepam, a long-acting benzodiazepine, has general properties similar to diazepam but with less toxicity. Its action mainly involves modification in the limbic system region. Pinazepam appears to be associated with a particularly low hypnotic effect and a limited motor coordination impairment. It also shows less cortical activity at the anxiolytic level than does diazepam on EEG. Pharmacokinetics: Absorption: Rapidly absorbed from the gastrointestinal tract. Metabolism: Metabolised via N-1 dealkylation and C-3 hydroxylation. |
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Đặc tính
 Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 40391, Pinazepam. https://pubchem.ncbi.nlm.nih.gov/compound/Pinazepam. Accessed Dec. 28, 2021. |
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Phân loại MIMS
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Phân loại ATC
N05BA14 - pinazepam ; Belongs to the class of benzodiazepine derivatives anxiolytics. Used in the management of anxiety, agitation or tension.
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Tài liệu tham khảo
Janbroers JM. Pinazepam: Review of Pharmacological Properties and Therapeutic Efficacy. Clin Ther. 1984;6(4):434-50. Accessed 15/11/2021. PMID: 6147192 Anon. Pinazepam. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 12/11/2021. Buckingham R (ed). Pinazepam. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 12/11/2021. Domar (Eurodrug). MIMS Hong Kong. http://www.mims.com/hongkong. Accessed 12/11/2021. Domar (Eurodrug). MIMS Thailand. http://www.mims.com/thailand. Accessed 12/11/2021. Preston CL (ed). Pinazepam Drug Interactions. Stockley’s Drug Interactions [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 15/11/2021.
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