Phenol


Thông tin thuốc gốc
Chỉ định và Liều dùng
Mouth/Throat
Pain, oropharyngeal
Adult: For the temporary relief of minor mouth irritation, sore mouth or throat pain, and canker sore pain: As 1.4% spray: 1 spray to the affected area, allow to remain for at least 15 seconds then expectorate. May repeat every 2 hours as needed. As 0.6% oral rinse: Gargle or swish for 15 seconds then spit out; may repeat every 2 hours as necessary. Do not use >12 times daily. Consult the doctor if symptoms do not improve in 7 days, or if irritation, pain, and redness continue or worsen. As phenol 0.175% w/v and halogenated phenols 0.68% w/v aqueous solution: Dilute the solution with 5 parts water, then gargle bid. For common mouth ulcers: May apply the undiluted solution using a clean swab onto affected area(s) tid. Seek medical advice if symptoms persist for >14 days. Dosage recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: For the temporary relief of minor mouth irritation, sore mouth or throat pain, and canker sore pain: As 1.4% spray: ≥3 years Same as adult dose. Use in children <12 years must be supervised. As 0.6% oral rinse: 4 months to <12 years Apply to affected area with a clean swab up to 6 times daily; ≥12 years Same as adult dose. Dosage recommendations may vary among individual products and between countries (refer to specific product guidelines).

Oral
Pain, oropharyngeal
Adult: For the temporary relief of minor mouth irritation, sore mouth or throat pain, and canker sore pain: As 29 mg loz: Dissolve up to 2 loz slowly in the mouth every 2 hours as necessary. Check with the doctor if symptoms last for >7 days, or if irritation, pain, and redness continue or worsen.
Child: For the temporary relief of minor mouth irritation, sore mouth or throat pain, and canker sore pain: As 29 mg loz: 6-<12 years Dissolve 1 loz slowly in the mouth every 2 hours as needed. Max of 10 loz in 24 hours; ≥12 years Same as adult dose.

Parenteral
Sclerotherapy of haemorrhoids
Adult: For symptomatic treatment of internal haemorrhoids: As oily phenol 5% submucosal inj: 2-3 mL inj into the submucosal layer at the base of the haemorrhoid. Alternatively, 2-5 mL inj into the submucosal space of the haemorrhoid or into the apex of the haemorrhoid. Several inj may be given at different sites. Max: 10 mL at any one treatment session.
Child: Contraindicated.

Topical/Cutaneous
Antiseptic agent
Adult: For 1st aid to protect minor scrapes, cuts, or burns from skin infection: As 1.5% paint: Apply a small amount to the affected area 1-3 times daily. As phenol 0.175% w/v and halogenated phenols 0.68% w/v aqueous solution: Dilute the solution with an equal quantity of water, then apply. May be used undiluted in emergencies.
Tương kỵ
Submucosal inj: Incompatible with alkaline salts and non-ionic surfactants.
Chống chỉ định
Hypersensitivity. Throat spray: Epiglottitis. Submucosal inj: Use over large areas. Neonates and children.
Thận trọng
Submucosal inj: Select the inj site carefully; not to be given via IV, IM or intrathecal route. Children. Pregnancy and lactation.
Tác dụng không mong muốn
Significant: Submucosal inj: Local ulceration or abscesses, increased systemic absorption and risk of toxic effect (if used over large areas). Rarely, pyrexia, dysuria, transient incontinence, impotence, and prostatic abscess (due to misplaced inj).
General disorders and administration site conditions: Inj site pain and discomfort, irritation, ulcer, tissue necrosis (submucosal inj).
Hepatobiliary disorders: Hepatitis (submucosal inj).
Immune system disorders: Hypersensitivity.
Nervous system disorders: Dizziness (submucosal inj).
Skin and subcutaneous tissue disorders: Skin irritation, pain, blanching or corrosion (topical).
Potentially Fatal: Submucosal inj: Necrotising fascitis, retroperitoneal sepsis (rare). Throat spray: Rarely, acute epiglottitis, oedema of the epiglottis and/or larynx.
Thông tin tư vấn bệnh nhân
Spray/rinse/solution: Do not swallow. As 1.4% spray, 0.6% oral rinse, 29 mg loz: Immediately consult the doctor the sore throat is severe, persists for >2 days and accompanied or followed by fever, headache, rash, nausea, or vomiting. Topical: Avoid contact with eyes. Do not apply to large areas of the body, deep puncture wounds, animal bites or serious burns. Do not bandage the affected area. As 0.15% paint: Do not use for >7 days unless directed by the doctor. May cause staining of the skin and clothing.
Ảnh hưởng đến kết quả xét nghiệm
Submucosal inj: Absorbed phenol may interfere with ferric chloride test for urinary ketones or salicylates, test for ionised serum Ca, serum sulfonamide measurement, Benedict's test for glycosuria and estimation of plasma epinephrine and norepinephrine by trihydroxyindole method.
Tác dụng
Description:
Mechanism of Action: Phenol is an antiseptic and disinfectant. It has also been used as a local anaesthetic and sclerosing agent. When used in haemorrhoids as a sclerosing agent, it causes fixation of the mucosa of the underlying muscles by producing submucosal fibrosis.
Pharmacokinetics:
Absorption: Readily absorbed from the gastrointestinal tract, and through intact skin and mucous membranes.
Metabolism: Metabolised in the liver into phenylglucuronide and phenyl sulfate; oxidised to catechol and quinol prior to further conjugation (small amounts).
Excretion: Via urine (as metabolites).
Đặc tính

Chemical Structure Image
Phenol

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 996, Phenol. https://pubchem.ncbi.nlm.nih.gov/compound/Phenol. Accessed June 30, 2021.

Bảo quản
Spray/rinse/solution/paint: Store between 20-25°C. Loz: Store below 30°C. Protect from humidity. Submucosal inj: Store below 30°C. Protect from light.
Phân loại MIMS
Thuốc trị bệnh vùng hậu môn trực tràng / Thuốc dùng trong viêm & loét miệng / Thuốc khử trùng & sát trùng da
Phân loại ATC
R02AA19 - phenol ; Belongs to the class of antiseptics used in throat preparations.
C05BB05 - phenol ; Belongs to the class of sclerosing agent used as local injection in antivaricose therapy.
D08AE03 - phenol ; Belongs to the class of phenol and derivatives antiseptics. Used in the treatment of dermatological diseases.
N01BX03 - phenol ; Belongs to the class of other agents used as local anesthetics.
Tài liệu tham khảo
AFT Pharmaceuticals Ltd. Phenol BP 5% w/v data sheet February 2019. Medsafe. http://www.medsafe.govt.nz. Accessed 03/03/2021.

Anon. Phenol. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 03/03/2021.

Buckingham R (ed). Phenol. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 03/03/2021.

Castellani Paint 1.5% (The Podiatree Company). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 03/03/2021.

Cepastat Extra Strength Lozenge (Insight Pharmaceuticals). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 03/03/2021.

Chloraseptic Sore Throat Spray Citrus, Cherry, Menthol (Prestige Brands Holdings, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 03/03/2021.

Joint Formulary Committee. Phenol. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 03/03/2021.

Oily Phenol 5% w/v Injection (Macarthys Laboratories Limited). MHRA. https://products.mhra.gov.uk. Accessed 03/03/2021.

TCP Liquid Antiseptic (Omega Pharma Ltd.). MHRA. https://products.mhra.gov.uk. Accessed 03/03/2021.

Ulcerease 0.6% Anesthetic Oral Rinse (Crown Laboratories). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 03/03/2021.

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