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Chỉ định và Liều dùng
Topical/Cutaneous
Recurrent herpes simplex labialis Adult: As 1% cream: Appy 2 hrly during waking hr (approx 8 times daily) for 4 days. Initiate treatment at earliest sign or symptom.
Child: >12 yr Same as adult dose. |
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Chống chỉ định
Hypersensitivity to penciclovir, famciclovir.
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Thận trọng
Immunocompromised patients (e.g. AIDS patients, bone marrow transplant recipients). Not recommended for application to mucous membranes (e.g. eyes, mouth, nose, genitals). Pregnancy and lactation.
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Tác dụng không mong muốn
Headache, taste perversion, application site reactions (e.g. stinging, burning, numbness), pruritus, pain, rash, allergic reactions, contact dermatitis.
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Topical: B
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Chỉ số theo dõi
Monitor reduction in virus shedding, negative cultures for herpes virus; resolution of pain and healing of cold sore lesion.
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Tác dụng
Description:
Mechanism of Action: Penciclovir has in vitro and in vivo inhibitory activity against various Herpesviridae, including herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), varicella zoster virus (VZV), and EpsteinBarr virus (EBV). In cells infected w/ HSV-1 or HSV-2, viral thymidine kinase phosphorylates penciclovir to a monophosphate form which, in turn, is converted to penciclovir triphosphate by cellular kinases. Penciclovir triphosphate inhibits HSV polymerase competitively w/ deoxyguanosine triphosphate. Consequently, herpes viral DNA synthesis and, therefore, replication are selectively inhibited. Pharmacokinetics: Absorption: Not absorbed appreciably into systemic circulation following topical administration at single or multiple doses up to a total of 180 mg (approx 67 times the proposed daily clinical dose). |
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Đặc tính
 Source: National Center for Biotechnology Information. PubChem Database. Penciclovir, CID=135398748, https://pubchem.ncbi.nlm.nih.gov/compound/Penciclovir (accessed on Jan. 22, 2020) |
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Bảo quản
Store between 20-25°C.
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Phân loại MIMS
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Tài liệu tham khảo
Anon. Penciclovir. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 25/11/2014. Buckingham R (ed). Penciclovir. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 25/11/2014. Denavir Cream (Novartis Consumer Health Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 25/11/2014. McEvoy GK, Snow EK, Miller J et al (eds). Penciclovir (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 25/11/2014.
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