Thông tin thuốc của Oxytetracycline

Thông tin này không áp dụng cho tất cả các quốc gia. Vui lòng tham khảo thông tin kê toa lưu hành tại Việt Nam.

Thông tin thuốc gốc

Chỉ định và Liều dùng

Oral
Brucellosis

Adult: In combination with streptomycin: 500 mg 4 times daily. Dosage recommendations may vary among countries or individual products. Refer to specific product guidelines.
Child: ≥12 years Same as adult dose. Dosage recommendations may vary among countries or individual products. Refer to specific product guidelines.

Oral
Rectal infection due to Chlamydia trachomatis, Uncomplicated genital infections due to Chlamydia trachomatis

Adult: 500 mg 4 times daily for 7 days. Dosage recommendations may vary among countries or individual products. Refer to specific product guidelines.
Child: ≥12 years Same as adult dose. Dosage recommendations may vary among countries or individual products. Refer to specific product guidelines.

Oral
Acne vulgaris

Adult: 250-500 mg in single or divided doses for at least 3 months. Dosage recommendations may vary among countries or individual products. Refer to specific product guidelines.
Child: ≥12 years Same as adult dose. Dosage recommendations may vary among countries or individual products. Refer to specific product guidelines.

Oral
Nongonococcal urethritis

Adult: For cases associated with Ureaplasma urealyticum: 500 mg 4 times daily for 7 days. Dosage recommendations may vary among countries or individual products. Refer to specific product guidelines.
Child: ≥12 years Same as adult dose. Dosage recommendations may vary among countries or individual products. Refer to specific product guidelines.

Oral
Epididymo-orchitis

Adult: For the treatment of acute cases associated with Chlamydia trachomatis or Neisseria gonorrhoeae: 500 mg 4 times daily for 10 days. Dosage recommendations may vary among countries or individual products. Refer to specific product guidelines.
Child: ≥12 years Same as adult dose. Dosage recommendations may vary among countries or individual products. Refer to specific product guidelines.

Oral
Rosacea

Adult: For the treatment of severe cases: 250-500 mg in single or divided doses for at least 3 months. Dosage recommendations may vary among countries or individual products. Refer to specific product guidelines.

Oral
Primary syphilis, Secondary syphilis

Adult: As an alternative treatment: Early syphilis: 500 mg 4 times daily for 15 days. Latent syphilis of >1 year or of unknown duration, CV syphilis, or late benign syphilis (except neurosyphilis): 500 mg 4 times daily for 30 days. Dosage recommendations may vary among countries or individual products. Refer to specific product guidelines.
Child: ≥12 years Same as adult dose. Dosage recommendations may vary among countries or individual products. Refer to specific product guidelines.

Oral
Streptococcal infectious disease

Adult: Usual dosage range: 250-500 mg 6 hourly. Max treatment duration: 10 days. Dosage recommendations may vary among countries or individual products. Refer to specific product guidelines.
Child: ≥12 years Same as adult dose. Dosage recommendations may vary among countries or individual products. Refer to specific product guidelines.

Suy thận

Contraindicated.

Suy gan

Contraindicated.

Cách dùng

Should be taken on an empty stomach.

Chống chỉ định

Hypersensitivity to oxytetracycline or to other tetracycline antibiotics. Porphyria, SLE. Hepatic and renal impairment. Children <12 years. Pregnancy and lactation. Patients receiving vitamin A or retinoid therapy.

Thận trọng

Patient with myasthenia gravis. Children and elderly.

Tác dụng không mong muốn

Significant: Haematologic disorders (e.g. haemolytic anaemia, thrombocytopenia, neutropenia, eosinophilia), increased BUN, intracranial hypertension, photosensitivity, overgrowth of non-susceptible organisms, permanent yellow-grey-brown tooth discolouration (during the period of tooth development, in the last half of pregnancy, children <12 years), enamel hypoplasia (long-term use or repeated short-term courses), fatty liver degeneration, pancreatitis (high doses).
Cardiac disorders: Pericarditis.
Endocrine disorders: Brown-black microscopic discolouration of thyroid tissue (prolonged use).
Gastrointestinal disorders: Gastrointestinal irritation, nausea, abdominal discomfort, vomiting, diarrhoea, anorexia, dysphagia, pseudomembranous colitis, glossitis, rectal irritation; oropharyngeal or intestinal candidiasis.
Hepatobiliary disorders: Hepatotoxicity (e.g. hepatitis, jaundice, hepatic failure).
Immune system disorders: Hypersensitivity reactions.
Renal and urinary disorders: Renal dysfunction.
Skin and subcutaneous tissue disorders: Macropapular and erythematous rash, urticaria, angioneurotic oedema, anaphylaxis, anaphylactoid purpura, exfoliative dermatitis, exacerbation of SLE.

Thông tin tư vấn bệnh nhân

This drug may cause photosensitivity reactions; avoid exposure to direct sunlight or UV light and apply sunscreen when going outdoors.

Chỉ số theo dõi

Perform culture and susceptibility tests prior to treatment initiation; consult local institutional recommendations before treatment initiation due to antibiotic resistance risks. Monitor CBC, renal function, and LFTs (in patients on long-term therapy).

Tương tác

Impaired absorption with antacids, Fe, Al, Ca, Mg, Zn, and anti-diarrhoeal preparations (e.g. kaolin-pectin, bismuth subsalicylate). May impair renal function with diuretics. May depress plasma prothrombin activity; dosage reduction of anticoagulants may be needed. May prolong the therapeutic activity of coumarin anticoagulants. May increase the hypoglycaemic effects of insulin and sulfonylureas. May diminish the therapeutic effect of penicillin. May cause breakthrough bleeding with oral contraceptives.
Potentially Fatal: Increased risk of benign intracranial hypertension with vitamin A or retinoids. Increased risk of nephrotoxicity with methoxyflurane or other nephrotoxic drugs.

Tương tác với thức ăn

Reduced absorption with food, milk, and dairy products.

Tác dụng

Description:
Mechanism of Action: Oxytetracycline, is a broad spectrum tetracycline derivative that exhibits its bacteriostatic action against a wide range of gram-positive and gram-negative organisms by inhibiting bacterial protein synthesis.
Pharmacokinetics:
Absorption: Incompletely and irregularly absorbed from the gastrointestinal tract. Time to peak plasma concentration: Approx 1-4 hours.
Distribution: Widely distributed throughout the body tissues and fluids. Crosses the placenta and enters breast milk. Plasma protein binding: Approx 20-40%.
Excretion: Via urine (40-70%); faeces. Elimination half-life: Approx 6-12 hours.

Đặc tính

Chemical Structure Image — **Oxytetracycline**

Bảo quản

Store below 25°C.

Phân loại MIMS

Tetracyclin

Phân loại ATC

J01AA06 - oxytetracycline ; Belongs to the class of tetracyclines. Used in the systemic treatment of infections.

Tài liệu tham khảo

Anon. Oxytetracycline. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 08/10/2021.

Buckingham R (ed). Oxytetracycline. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 08/10/2021.

Joint Formulary Committee. Oxytetracycline. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 08/10/2021.

Oxytetracycline 250 mg Tablets (Crescent Pharma Ltd.). MHRA. https://products.mhra.gov.uk. Accessed 08/10/2021.

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