Oxyphenonium

Urinary outflow obstruction, paralytic ileus, myasthenia gravis.

Children; elderly; benign prostatic hyperplasia; acute MI, cardiac failure, hypertension, thyrotoxicosis; pregnancy and lactation; fever; angle-closure glaucoma.

Dryness of mouth, difficulty in talking/swallowing; reduced bronchial secretions; blurring of vision, photophobia; bradycardia followed by tachycardia and arrhythmias; urinary retention, constipation, vomiting, nausea; confusion and giddiness.
Potentially Fatal: Arrhythmias (especially after MI).

Reduced gastric motility interferes with absorption of other drugs. Effects potentiated by other antimuscarinics including amantadine, some antihistamines, phenothiazines and TCA.

Description:
Mechanism of Action: Oxyphenonium is a quarternary ammonium antimuscarinic.

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