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Chỉ định và Liều dùng
Oral
Allergic conditions Adult: As anhydrous substance: 30 mg bid.
Child: As anhydrous substance: Initially, 0.5 mg/kg bid. Optimal dose: 0.5-1 mg/kg bid. |
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Suy gan
Initiate at 50% of the normal dose.
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Cách dùng
Should be taken with food.
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Chống chỉ định
Premature infants or full-term neonates. Pregnancy and lactation.
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Thận trọng
May impair ability to drive and operate machinery. Angle-closure glaucoma, urinary retention, prostatic hyperplasia or pyloroduodenal obstruction; hepatic impairment. Elderly. Not for acute asthma. Children <6 yr.
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Tác dụng không mong muốn
Sedation, inability to concentrate, lassitude, dizziness, hypotension, muscular weakness, incoordination. Nausea, vomiting, diarrhoea or constipation, epigastric pain. Headache, blurred vision, tinnitus, elation or depression, irritability, nightmares, anorexia, urinary retention, dry mouth, chest tightness, dysuria and tingling. Rash, urticaria. Agranulocytosis, haemolytic anaemia. Increased appetite, wt gain. Convulsions, increased transaminase, hepatitis. Dyskinetic neurological reactions (infants and young children).
Potentially Fatal: Anaphylactoid reactions, angioedema. |
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Quá liều
Symptoms: Somnolence, stupor, dyskinesia, torticollis, oculogyria, dystonia, hypertonia, hyperexcitability, agitation, mydriasis, tachycardia, bradycardia, generalised muscle spasms. Excitement, hallucinations, muscle tremors, ataxia, convulsions, dry mouth, flushed face, mydriasis, hyperpyrexia in infants and children. Coma and cardiorespiratory collapse (terminal events). Management: Symptomatic and supportive. Extrapyramidal symptoms have been successfully treated with anticholinergic agents; no specific antidote.
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Tương tác
May enhance effects of CNS depressants e.g. alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives and tranquillizers. Anticholinergic effects of atropine, TCAs, MAOIs may be enhanced. May mask signs of ototoxicity caused by aminoglycosides.
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Ảnh hưởng đến kết quả xét nghiệm
May interfere with skin testing.
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Tác dụng
Description:
Mechanism of Action: Oxatomide is a piperazine derivative sedating antihistamine. It also has mast-cell stabilising properties. Pharmacokinetics: Absorption: Almost completely absorbed from the GI tract. Peak plasma levels within 2 hr. Distribution: Protein-binding: 98%. Metabolism: Hepatic via aromatic hydroxylation, oxidative N-dealkylation and conjugation. Excretion: Mainly via faeces (60%) from the bile; via urine. Half-life: 14 hr. |
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Bảo quản
Store below 25°C. Protect from light.
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Phân loại MIMS
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Đăng xuất
