Chống chỉ định
Pre-existing hypertension; occlusive vascular disease; phaeochromocytoma; angle-closure glaucoma (eye drops); hypersensitivity; cardiac arrhythmias.
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Thận trọng
CV diseases; hyperthyroidism; DM; Parkinson's disease; elderly; pregnancy, lactation, prostate disorders.
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Tác dụng không mong muốn
CNS effects; GI disturbances; epigastric pain; CV disorders; difficulty in micturition with urinary retention; dyspnoea; hyperglycaemia; sweating; hypersalivation; weakness, tremors; coldness of extremities; hypokalaemia, tachycardia, reflex bradycardia. Gangrene, tissue necrosis and sloughing (extravasation), especially when used in addition to local anaesthetics.
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Tương tác
May antagonise effects of antihypertensives, guanethidine. Increased risk of ventricular fibrillation with inhalational anaesthetics. Pressor effects may be enhanced by ergot alkaloids or oxytocin. Additive toxicity may occur with antiparkinsonian drugs.
Potentially Fatal: Severe hypertension with MAOIs and other sympathomimetics. |
Tác dụng
Description:
Mechanism of Action: Octopamine is a sympathomimetic with predominantly α-adrenergic activity used in the treatment of hypotensive states. |
Phân loại MIMS
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