Nitrendipine

Oral
Hypertension

Initially, 10 mg daily.

Should be taken with food.

Pregnancy and lactation.

Patient with cardiogenic shock or severe aortic stenosis. Hepatic impairment. Elderly.

Eye disorders: Eye pain.
Gastrointestinal disorders: Nausea, gingival hyperplasia, gastrointestinal disturbance.
General disorders and administration site conditions: Lethargy, peripheral oedema.
Nervous system disorders: Dizziness, headache.
Psychiatric disorders: Depression.
Renal and urinary disorders: Increased micturition frequency.
Vascular disorders: Hypotension, flushing.

Increased plasma concentration with cimetidine and ranitidine. Decreased plasma concentration and exposure with bile acids (e.g. ursodeoxycholic acid, chenodeoxycholic acid).

Grapefruit juice may increase the bioavailability of nitrendipine.

Description:
Mechanism of Action: Nitrendipine is a dihydropyridine Ca channel blocker. It inhibits the influx of Ca ions through a voltage-dependent Ca channel in vascular smooth muscle cells.
Pharmacokinetics:
Absorption: Well absorbed from the gastrointestinal tract. Absolute bioavailability: Approx 10-30%. Time to peak plasma concentration: Within 1-3 hours.
Distribution: Plasma protein binding: Approx 98%.
Metabolism: Extensively metabolised in the liver. Undergoes extensive first-pass metabolism.
Excretion: Via urine and faeces (as inactive metabolites, <0.1% as unchanged drug). Terminal elimination half-life: Approx 10-22 hours.

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 4507, Nitrendipine. https://pubchem.ncbi.nlm.nih.gov/compound/Nitrendipine. Accessed Feb. 27, 2023.

Store below 25°C.

Thuốc đối kháng calci

C08CA08 - nitrendipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.

Triggle DJ. Antihypertensive Mechanism of Action and Binding Sites of Nitrendipine. The American Journal of Cardiology. 1986 Sep;58(8):D35-D38. https://doi.org/10.1016/0002-9149(86)90423-6. Accessed 20/02/2023

Anon. Nitrendipine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 15/11/2022.

Buckingham R (ed). Nitrendipine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 15/11/2022.

Ditrenil (Siam Bheasach). MIMS Thailand. http://www.mims.com/thailand. Accessed 15/11/2022.

Preston CL (ed). Calcium-channel Blockers + Grapefruit Juice. Stockley’s Drug Interactions [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 15/11/2022.

Preston CL (ed). Calcium-channel Blockers + H2-receptor Antagonists. Stockley’s Drug Interactions [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 20/02/2023.

Preston CL (ed). Calcium-channel Blockers; Nitrendipine + Bile Acids. Stockley’s Drug Interactions [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 15/11/2022.