Nilvadipine

Oral
Cerebrovascular disorders

Oral
Angina pectoris

Oral
Hypertension

Cardiogenic shock, recent MI, unstable angina, severe renal impairment, CHF, aortic stenosis.

Headache, peripheral oedema, dizziness, fatigue, flushing, paradoxical increase in ischaemic chest pain.

Increased hypotensive effects with other antihypertensive drugs such as β-blockers, some antipsychotics, ranitidine, and cimetidine.

Increased bioavailability with grapefruit juice.

Description:
Mechanism of Action: Nilvadipine is a dihydropyridine calcium-channel blocker. It is a peripheral and coronary vasodilator, but has little or no effect on cardiac conduction and negative inotropic activity is rarely seen at therapeutic doses. It results in vasodilatation leading to reduced peripheral resistance, BP, and afterload, increased coronary blood flow, and a reflex increase in heart rate. This results in an increase in myocardial oxygen supply and cardiac output.

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